Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan.
Intern Med. 2021 Jan 15;60(2):305-308. doi: 10.2169/internalmedicine.5536-20. Epub 2020 Sep 12.
Combined central and peripheral demyelination (CCPD) causes demyelination in both the central and peripheral nervous systems. Anti-neurofascin 155 antibody plays an important pathogenic role in CCPD, but evidence concerning an association between this antibody and CCPD remains inconclusive. Although there have been no reports of precedent optic neuritis developing into CCPD, we herein report a Japanese man in whom optic neuritis recurred four times over nine years and who developed CCPD without positive anti-neurofascin 155 antibody. This case suggests the possibility of developing CCPD after optic nerve neuritis and the existence of an unknown antibody that induces CCPD.
联合性中枢及周围脱髓鞘病变（CCPD）可导致中枢及周围神经系统脱髓鞘。抗神经束蛋白 155 抗体在 CCPD 中起着重要的致病作用，但关于该抗体与 CCPD 之间的关联证据仍不明确。尽管尚无先例报道视神经炎发展为 CCPD，但我们在此报告了一例日本男性，他在 9 年内反复发作了 4 次视神经炎，且未出现抗神经束蛋白 155 抗体阳性而发展为 CCPD。该病例提示视神经炎后可能发生 CCPD，并且存在诱导 CCPD 的未知抗体。
