Kitada Mari, Suzuki Hidekazu, Ichihashi Juri, Inada Rino, Miyamoto Katsuichi, Takahashi Toshiyuki, Mitsui Yoshiyuki, Fujihara Kazuo, Kusunoki Susumu
Department of Neurology, Kinki University School of Medicine, Japan.
Intern Med. 2012;51(17):2443-7. doi: 10.2169/internalmedicine.51.7590. Epub 2012 Sep 1.
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.
视神经脊髓炎谱系障碍（NMOSD）的特征是伴有抗水通道蛋白4（AQP4）抗体的视神经炎或横贯性脊髓炎（1）。我们在此报告一例患有NMOSD且伴有周围神经病变的患者。一名58岁女性出现步态障碍和下肢感觉障碍。她表现为伴有抗AQP4抗体的纵向广泛横贯性脊髓炎。神经传导研究显示有脱髓鞘改变。实验室检查结果显示丙型肝炎病毒（HCV）感染。免疫治疗后她的周围神经病变有所改善。此前尚无NMO或NMOSD合并神经病变的报道。HCV感染或抗AQP4抗体以外未明确的体液因素可能导致了她的周围神经病变。
