Child Neuropsychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Department of Neuroscience (DINOGMI), IRCCS Istituto Giannina Gaslini, University of Genoa, Italy.
Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
J Neuroimmunol. 2023 Nov 15;384:578213. doi: 10.1016/j.jneuroim.2023.578213. Epub 2023 Sep 27.
The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.
联合中枢和外周脱髓鞘（CCPD）的发生较为罕见，数据仅限于小型病例和队列研究，主要涉及成年人。在少数患者中报道了抗髓鞘少突胶质细胞糖蛋白（MOG）抗体阳性，从而扩大了抗 MOG 相关疾病（MOGAD）的范围。我们描述了一例 7 岁女孩，视神经炎 8 年后出现外周脱髓鞘，细胞基础检测中抗 MOG 抗体呈波动性阳性。通过文献复习，MOGAD-CCPD 在儿童中非常罕见，尤其是在病程不同步的情况下。临床医生应考虑到这种可能性，以便在不典型脱髓鞘综合征的诊断中更好地定义，这具有治疗意义。
