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作者信息

Falk Fabian, Zhou Zekun, Klinkusch Andreas, Weber Laura, Breitling Frank

机构信息

AG Peptidarrays, Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie, Herrmann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Deutschland.

出版信息

Biospektrum (Heidelb). 2020;26(5):556-558. doi: 10.1007/s12268-020-1440-0. Epub 2020 Sep 5.

Abstract

Since decades antibodies are used for diagnosis e. g. by detecting patient antibodies that specifically bind to Influenza virus proteins. We predict these diagnostic questions will be parallelized to diagnose all known disease specific antibodies at once. These tests will ask in addition, which unknown antibodies patrol in a patient's blood, and what exactly they bind to. Thereby, we expect to find antibody species that correlate to hitherto enigmatic diseases or have specialized functions.

摘要

几十年来,抗体一直用于诊断,例如通过检测与流感病毒蛋白特异性结合的患者抗体。我们预计这些诊断问题将被并行化,以便一次性诊断所有已知的疾病特异性抗体。此外,这些检测还将询问患者血液中巡逻的未知抗体是什么,以及它们具体结合的是什么。由此,我们期望找到与迄今神秘疾病相关或具有特殊功能的抗体种类。

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本文引用的文献

1
Elastic reversible valves on centrifugal microfluidic platforms.
Lab Chip. 2019 Mar 13;19(6):1090-1100. doi: 10.1039/c8lc00849c.
2
Single amino acid fingerprinting of the human antibody repertoire with high density peptide arrays.
J Immunol Methods. 2017 Apr;443:45-54. doi: 10.1016/j.jim.2017.01.012. Epub 2017 Feb 3.
4
Regulatory B cells: origin, phenotype, and function.
Immunity. 2015 Apr 21;42(4):607-12. doi: 10.1016/j.immuni.2015.04.005.
6
Combinatorial synthesis of peptide arrays with a laser printer.
Angew Chem Int Ed Engl. 2008;47(37):7132-5. doi: 10.1002/anie.200801616.
7
In situ synthesis of protein arrays.
Curr Opin Biotechnol. 2008 Feb;19(1):4-9. doi: 10.1016/j.copbio.2007.11.009. Epub 2008 Jan 18.
8
Combinatorial synthesis of peptide arrays onto a microchip.
Science. 2007 Dec 21;318(5858):1888. doi: 10.1126/science.1149751.
9
Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.
J Immunol. 2002 Jul 15;169(2):1102-9. doi: 10.4049/jimmunol.169.2.1102.
10
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.
Science. 1985 Jun 14;228(4705):1315-7. doi: 10.1126/science.4001944.

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