血清碱性磷酸酶是肢体骨转移性疾病的一个预后标志物。
Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity.
作者信息
Thio Quirina C B S, Karhade Aditya V, Notman Emily, Raskin Kevin A, Lozano-Calderón Santiago A, Ferrone Marco L, Bramer Jos A M, Schwab Joseph H
机构信息
Department of Orthopedic Surgery, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
J Orthop. 2020 Aug 17;22:346-351. doi: 10.1016/j.jor.2020.08.008. eCollection 2020 Nov-Dec.
PURPOSE
The purpose of this study was to determine the prognostic value of serum alkaline phosphatase for treatment decision making in metastatic bone disease.
METHODS
1090 patients who underwent surgery for extremity metastatic disease were retrospectively identified at two tertiary care centers. The association between alkaline phosphatase and mortality was assessed by bivariate and multivariate analyses.
RESULTS
Three-month and one-year mortality rates were 305 (29%) and 639 (62%), respectively. Alkaline phosphatase was associated with mortality at both three months and one year.
CONCLUSION
Serum alkaline phosphatase may be a useful marker in prognostic algorithms for patients with extremity metastatic disease.
目的
本研究的目的是确定血清碱性磷酸酶在转移性骨病治疗决策中的预后价值。
方法
在两个三级医疗中心对1090例接受肢体转移性疾病手术的患者进行回顾性分析。通过双变量和多变量分析评估碱性磷酸酶与死亡率之间的关联。
结果
三个月和一年的死亡率分别为305例（29%）和639例（62%）。碱性磷酸酶在三个月和一年时均与死亡率相关。
结论
血清碱性磷酸酶可能是肢体转移性疾病患者预后评估算法中的一个有用指标。
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