骨关节炎与认知正常的老年人海马体积更快缩小有关。
Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People.
作者信息
Li Xiang, Tong Qiaowen, Gao Jianqing, Liu Cailong, Liu Yangbo
机构信息
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Neurology, Wenzhou People's Hospital, Wenzhou, China.
出版信息
Front Aging Neurosci. 2020 Aug 14;12:190. doi: 10.3389/fnagi.2020.00190. eCollection 2020.
OBJECTIVE
To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 10) over time among cognitively normal older people.
METHODS
We examined the cross-sectional and longitudinal associations of OA with HpVR among individuals with normal cognition (NC) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. At baseline, a total of 372 individuals with NC were included.
RESULTS
In the cross-sectional analyses of baseline data, we did not find a significant relationship between OA and HpVR among individuals with NC. However, in the longitudinal analyses, OA was significantly associated with change in HpVR over time among individuals with NC. Specifically, compared with individuals without OA, those with OA showed a faster decline in HpVR over time when controlling for other potential confounders, including age, educational attainment, gender, and APOE4 genotype.
CONCLUSION
OA status was significantly associated with a change in HpVR over time among individuals with NC.
目的
研究认知功能正常的老年人中，骨关节炎（OA）是否与校正海马体积（HpVR：海马体积/颅内体积×10）随时间的变化相关。
方法
我们在阿尔茨海默病神经影像倡议（ADNI）研究中，研究了骨关节炎与认知功能正常（NC）个体的HpVR之间的横断面和纵向关联。基线时，共纳入372名认知功能正常的个体。
结果
在基线数据的横断面分析中，我们未发现骨关节炎与认知功能正常个体的HpVR之间存在显著关系。然而，在纵向分析中，骨关节炎与认知功能正常个体的HpVR随时间的变化显著相关。具体而言，在控制包括年龄、教育程度、性别和APOE4基因型等其他潜在混杂因素后，与无骨关节炎的个体相比，有骨关节炎的个体HpVR随时间下降得更快。
结论
在认知功能正常的个体中，骨关节炎状态与HpVR随时间的变化显著相关。
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