Cohen Joshua T, Miner Thomas J, Vezeridis Michael P
Department of Surgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Melanoma Manag. 2020 Aug 25;7(3):MMT47. doi: 10.2217/mmt-2020-0006.
The neutrophil-to-lymphocyte ratio (NLR) is gaining traction as a biomarker with utility in a variety of malignancies including melanoma. Intact lymphocyte function is necessary for tumor surveillance and destruction, and neutrophils play a role in suppressing lymphocyte proliferation and in the induction of lymphocyte apoptosis. Early research in melanoma indicates that in high-risk localized melanoma, a high NLR is correlated with worse overall and disease-free survival. Similarly, in metastatic melanoma treated with both metastasectomy and immunotherapies, an elevated NLR is predictive of shortened overall survival and progression-free survival. Future studies incorporating NLR into more traditional melanoma prognostic markers while employing more granular outcomes, are needed to realize the full potential of NLR.
中性粒细胞与淋巴细胞比值（NLR）作为一种生物标志物，在包括黑色素瘤在内的多种恶性肿瘤中具有应用价值，正越来越受到关注。完整的淋巴细胞功能对于肿瘤监测和破坏至关重要，而中性粒细胞在抑制淋巴细胞增殖和诱导淋巴细胞凋亡方面发挥作用。黑色素瘤的早期研究表明，在高危局限性黑色素瘤中，高NLR与较差的总生存率和无病生存率相关。同样，在接受转移灶切除术和免疫疗法治疗的转移性黑色素瘤中，NLR升高预示着总生存期和无进展生存期缩短。未来需要开展更多研究，将NLR纳入更传统的黑色素瘤预后标志物中，同时采用更细化的结果指标，以充分发挥NLR的潜力。
