Zucchelli Eleonora, Majid Qasim A, Foldes Gabor
National Heart and Lung Institute, Imperial College London, London, UK.
Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Vasc Biol. 2019 Dec 3;1(1):H135-H143. doi: 10.1530/VB-19-0026. eCollection 2019.
Angiogenesis and vasculogenesis are complex processes by which new blood vessels are formed and expanded. They play a pivotal role not only in physiological development and growth and tissue and organ repair, but also in a range of pathological conditions, from tumour formation to chronic inflammation and atherosclerosis. Understanding the multistep cell-differentiation programmes and identifying the key molecular players of physiological angiogenesis/vasculogenesis are critical to tackle pathological mechanisms. While many questions are yet to be answered, increasingly sophisticated , and models of angiogenesis/vasculogenesis, together with cutting-edge imaging techniques, allowed for recent major advances in the field. This review aims to summarise the three-dimensional models available to study vascular network formation and to discuss advantages and limitations of the current systems.
血管生成和血管发生是形成和扩展新血管的复杂过程。它们不仅在生理发育、生长以及组织和器官修复中发挥关键作用，而且在一系列病理状况中也起着关键作用，从肿瘤形成到慢性炎症和动脉粥样硬化。了解多步骤细胞分化程序并确定生理性血管生成/血管发生的关键分子参与者对于解决病理机制至关重要。尽管仍有许多问题有待解答，但越来越复杂的血管生成/血管发生模型以及前沿成像技术，使得该领域最近取得了重大进展。本综述旨在总结可用于研究血管网络形成的三维模型，并讨论当前系统的优缺点。
