原位肝移植治疗暴发性和亚急性肝衰竭。
Orthotopic liver transplantation for fulminant and subacute hepatic failure.
作者信息
Stieber A C, Ambrosino G, Van Thiel D, Iwatsuki S, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
出版信息
Gastroenterol Clin North Am. 1988 Mar;17(1):157-65.
The fulminant hepatic failure (FHF) is a condition characterized by massive hepatocyte necrosis and one that is associated with severe liver and/or other organ-systems insufficiency leading to death in up to 85 per cent of the cases with medical treatment only. Although various expedients have been tried in order to save these patients, the necrosis is usually so massive that it is beyond regeneration. At present, the only hope lies with orthotopic liver transplantation (OLTx), which has become progressively more successful during the last few years. Various considerations pertaining to OLTx are discussed, as well as our series of 40 patients who were transplanted for FHF, with a survival of 57 per cent.
暴发性肝衰竭（FHF）是一种以大量肝细胞坏死为特征的疾病，与严重的肝脏和/或其他器官系统功能不全相关，仅通过药物治疗，高达85%的病例会导致死亡。尽管为了挽救这些患者尝试了各种权宜之计，但坏死通常非常严重，无法再生。目前，唯一的希望在于原位肝移植（OLTx），在过去几年中其成功率逐渐提高。本文讨论了与原位肝移植相关的各种因素，以及我们对40例因暴发性肝衰竭接受移植患者的系列研究，其生存率为57%。
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