急性肝衰竭中类固醇疗法的随机试验。来自欧洲肝脏研究协会（EASL）的报告。
Randomised trial of steroid therapy in acute liver failure. Report from the European Association for the Study of the Liver (EASL).
出版信息
Gut. 1979 Jul;20(7):620-3. doi: 10.1136/gut.20.7.620.
Abstract
A randomised, un-blinded clinical trial of hydrocortisate treatment in acute liver failure was carried out by 17 European centres. During a four year period 40 patients entered the study, 26 in the steroid group and 14 in the control group. The groups were found to be comparable, and the survival was 12 and 14%, respectively. A number of clinical and laboratory data, particularly HBsAg-positivity, appeared to carry some prognostic information, irrespective of treatment, but statistical significance was not achieved. Pooling of the present results with those from relevant published reports indicates a significant negative effect of steroid treatment in acute liver failure (P less than 0.2).
摘要
17个欧洲中心开展了一项关于氢化可的松治疗急性肝衰竭的随机、非盲法临床试验。在四年期间，40名患者进入研究，其中26名在类固醇组，14名在对照组。发现两组具有可比性，生存率分别为12%和14%。一些临床和实验室数据，特别是乙肝表面抗原阳性，似乎携带一些预后信息，无论治疗如何，但未达到统计学显著性。将目前的结果与相关已发表报告的结果合并表明，类固醇治疗对急性肝衰竭有显著的负面影响（P小于0.2）。
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