成人急性和亚急性肝衰竭的原位肝移植
Orthotopic liver transplantation for acute and subacute hepatic failure in adults.
作者信息
Peleman R R, Gavaler J S, Van Thiel D H, Esquivel C, Gordon R, Iwatsuki S, Starzl T E
出版信息
Hepatology. 1987 May-Jun;7(3):484-9. doi: 10.1002/hep.1840070312.
The role of liver transplantation in 29 patients with fulminant and subacute hepatic failure due to a variety of different causes was examined by comparing the outcome and a variety of "hospitalization" variables. Transplanted patients (n = 13) were more likely to survive (p less than 0.05), were younger (p less than 0.05) and spent more time in the hospital (p less than 0.025) than did those who were not transplanted (n = 16). Despite spending a much longer time in the hospital, transplanted patients spent less time in the intensive care unit (p less than 0.05) in coma (p less than 0.01) and on a respirator (p less than 0.01) than did those not transplanted. Most importantly, the survival rate for transplanted patients was significantly improved (p less than 0.05) as compared to those not transplanted. We conclude that liver transplantation can be applied successfully to the difficult clinical problem of fulminant and subacute hepatic failure.
通过比较29例因各种不同病因导致暴发性和亚急性肝衰竭患者的预后及一系列“住院”变量，研究了肝移植在这些患者中的作用。与未接受移植的患者（n = 16）相比，接受移植的患者（n = 13）更有可能存活（p < 0.05），年龄更小（p < 0.05），住院时间更长（p < 0.025）。尽管接受移植的患者住院时间长得多，但与未接受移植的患者相比，他们在重症监护病房的时间更短（p < 0.05），昏迷时间更短（p < 0.01），使用呼吸机的时间更短（p < 0.01）。最重要的是，与未接受移植的患者相比，接受移植的患者的存活率显著提高（p < 0.05）。我们得出结论，肝移植可以成功应用于暴发性和亚急性肝衰竭这一棘手的临床问题。
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