Szalai Bálint, Hercegh Éva, Magyar Nóra, Déri Dániel, Rózsa Mónika, Molnár Zsuzsanna, Kuti Dávid, Kis Zoltán, Szomor Katalin, Takács Mária, Barcsay Erzsébet
Mikrobiológiai Referencia Laboratóriumi Főosztály, Virológiai Laboratóriumi Osztály,Nemzeti Népegészségügyi Központ, Budapest, Albert Flórián út 2-6., 1097.
Járványügyi és Infekciókontroll Főosztály, Járványügyi és Védőoltási Surveillance Osztály,Nemzeti Népegészségügyi Központ, Budapest.
Orv Hetil. 2020 Sep;161(38):1619-1622. doi: 10.1556/650.2020.32000.
In Hungary, SARS-CoV-2 was first detected in the swab samples of two Iranian patients on March 4, 2020. After finding the first positive cases, the question arose whether the virus had entered Hungary and caused infections before this date. Before March 4, 2020, except for the two above-mentioned samples, none of the 224 swab samples received specifically for SARS-CoV-2 tested positive.
The National Reference Laboratory for Respiratory Viruses of the National Public Health Center aimed to carry out a retrospective study of the swab and other samples taken for testing respiratory virus infections between January 1, and April 19, 2020 sent by sentinel physicians within the influenza surveillance for diagnostic purposes.
For the study, we used swab samples taken weekly by sentinel physicians of the influenza surveillance service, and other samples received for diagnostic purposes. Tests were performed using real-time PCR.
All the 465 swab samples sent by sentinel physicians were found to be SARS-CoV-2 negative. Also, of the 551 samples collected for diagnostic reasons of other respiratory viruses, no SARS-CoV-2 positive was found among those taken before March 4.
Based on our data, it is very likely that prior to the first cases diagnosed on March 4, 2020, SARS-CoV-2 did not cause clinically symptomatic infections in Hungary. Orv Hetil. 2020; 161(38): 1619-1622.
2020年3月4日，匈牙利首次在两名伊朗患者的拭子样本中检测到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。发现首例阳性病例后，出现了该病毒是否在这一日期之前已进入匈牙利并引发感染的问题。在2020年3月4日之前，除上述两个样本外，专门用于检测SARS-CoV-2的224个拭子样本均未检测呈阳性。
国家公共卫生中心的国家呼吸道病毒参考实验室旨在对2020年1月1日至4月19日期间哨点医生为诊断目的在流感监测中送检的用于检测呼吸道病毒感染的拭子及其他样本进行回顾性研究。
在本研究中，我们使用了流感监测服务的哨点医生每周采集的拭子样本以及为诊断目的接收的其他样本。检测采用实时聚合酶链反应（PCR）进行。
哨点医生送检的所有465个拭子样本均被发现SARS-CoV-2呈阴性。此外，在因其他呼吸道病毒诊断原因采集的551个样本中，3月4日之前采集的样本中未发现SARS-CoV-2呈阳性。
根据我们的数据，2020年3月4日首例确诊病例之前，SARS-CoV-2很可能未在匈牙利引起临床症状性感染。《匈牙利医学周报》。2020年；161(38): 1619 - 1622。
