Fraunhofer-Institute for Applied Polymer Research (IAP), Potsdam-Golm, Germany.
Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology, Senftenberg, Germany.
Clin Hemorheol Microcirc. 2020;76(2):309-316. doi: 10.3233/CH-209206.
Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
血栓事件源于不同的病理，并是诸如中风或心肌梗死等严重疾病的根本原因。最近的基础研究揭示了食物摄取、食物转化和肠道代谢之间的联系。肠道微生物从膳食营养素（如胆碱、卵磷脂和左旋肉碱）产生的三甲胺 N-氧化物（TMAO）与心血管疾病的发展有关。在本综述中，我们系统地概述了 TMAO 对血小板和内皮细胞等血液成分的影响，这两者都是血栓形成过程中的关键参与者。总之，肠道微生物组、TMAO 和心血管疾病之间存在着一种机制上的相关性，这强调了肠道微生物组的重要性。
