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因感音神经性听力损失行口服和鼓室内类固醇治疗后出现砧骨坏死 1 例

A Case of Incus Necrosis Following Oral and Intratympanic Steroid Administration for Sensorineural Hearing Loss.

机构信息

Division of Otolaryngology, George Washington University School of Medicine and Health Sciences, Washington, DC.

出版信息

Otol Neurotol. 2020 Oct;41(9):1210-1213. doi: 10.1097/MAO.0000000000002799.

Abstract

OBJECTIVE

Intratympanic (IT) steroid injections are often used for the treatment of inner ear pathologies, including sudden sensorineural hearing loss. IT steroids are also commonly used in conjunction with or in case of systemic steroid therapy failure. They are viable options for patients who cannot endure side effects or are at high risk of complications from systemic therapy. The duration of treatment, strength, and type of steroid, and number of IT injections are important factors that impact possible treatment complications. Reported complications, though uncommon, include tympanic membrane perforation, otalgia, vertigo, otitis media, and acne. In this report, we explore a novel case of incus necrosis associated with oral and/or IT steroid administration.

STUDY DESIGN

Clinical Capsule Report.

SETTING

Tertiary Academic Center.

PATIENT

We present a case of a 70-year-old male with sudden sensorineural hearing loss who developed incus necrosis and conductive hearing loss following treatment with oral and intratympanic steroids.

INTERVENTION

The patient underwent a left tympanoplasty with ossicular chain reconstruction to treat the conductive component of his hearing loss.

RESULTS

The left tympanoplasty almost fully-resolved the conductive component of his hearing loss. However, intraoperative and CT assessment of the temporal bone revealed resorption of the long process of the incus, with otherwise normal-appearing ossicles.

CONCLUSION

We report the first case of possible steroid-induced necrosis of the long process of the incus. Owing to its tenuous blood supply, the incus may be predisposed to steroid-induced osteonecrosis similar to that of the femoral head.

摘要

目的

鼓室内(IT)类固醇注射常用于治疗内耳疾病,包括突发性聋。IT 类固醇也常用于与全身类固醇治疗联合使用或在全身类固醇治疗失败的情况下使用。对于不能耐受副作用或有全身治疗并发症高风险的患者,它们是可行的选择。治疗持续时间、类固醇的强度和类型以及 IT 注射次数是影响可能的治疗并发症的重要因素。尽管罕见,但报道的并发症包括鼓膜穿孔、耳痛、眩晕、中耳炎和痤疮。在本报告中,我们探讨了与口服和/或 IT 类固醇给药相关的砧骨坏死的一个新病例。

研究设计

临床案例报告。

设置

三级学术中心。

患者

我们报告了一例 70 岁男性,因突发性聋接受口服和鼓室内类固醇治疗后发生砧骨坏死和传导性聋。

干预措施

患者接受左侧鼓室成形术和听骨链重建术以治疗其听力损失的传导成分。

结果

左侧鼓室成形术几乎完全解决了他听力损失的传导成分。然而,颞骨的术中评估和 CT 显示砧骨长突吸收,其余听骨正常。

结论

我们报告了首例可能由类固醇引起的砧骨长突坏死的病例。由于其血液供应脆弱,砧骨可能容易发生类似于股骨头的类固醇诱导性骨坏死。

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