凝乳酶原的完整氨基酸序列。
The complete amino acid sequence of prochymosin.
作者信息
Foltmann B, Pedersen V B, Jacobsen H, Kauffman D, Wybrandt G
出版信息
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2321-4. doi: 10.1073/pnas.74.6.2321.
Abstract
The total sequence of 365 amino acid residues in bovine prochymosin is presented. Alignment with the amino acid sequence of porcine pepsinogen shows that 204 amino acid residues are common to the two zymogens. Further comparison and alignment with the amino acid sequence of penicillopepsin shows that 66 residues are located at identical positions in all three proteases. The three enzymes belong to a large group of proteases with two aspartate residues in the active center. This group forms a family derived from one common ancestor.
摘要
本文给出了牛凝乳酶原365个氨基酸残基的完整序列。与猪胃蛋白酶原的氨基酸序列比对显示，这两种酶原共有204个氨基酸残基。进一步与青霉蛋白酶的氨基酸序列进行比较和比对表明，在所有这三种蛋白酶中，有66个残基位于相同位置。这三种酶属于一大类在活性中心含有两个天冬氨酸残基的蛋白酶。该类蛋白酶构成了一个源于共同祖先的家族。
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The inactivation of pepsin by diazoacetylnorleucine methyl ester.重氮乙酰正亮氨酸甲酯对胃蛋白酶的失活作用。
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