Onitsuka A, Matsunami H, Senga S, Hino A, Ozeki Y, Hayashi M, Hirose M
First Department of Surgery, Gifu University School of Medicine, Gifu, Japan.
Nihon Geka Gakkai Zasshi. 1988 Mar;89(3):376-80.
Patients with advanced liver disease demonstrate characteristic plasma amino acid abnormalities. The response of plasma amino acid patterns after liver transplantation in those patients is unknown. Mongrel dogs were subjected to two experimental models, that is, one is total hepatectomy under veno-veno bypass as an assumption of an hepatic phase in liver transplantation and the another is splenectomy as control. In control group, BCAA/AAA ratio rose gradually during operation. The levels of methionine, glycine and alanine were significantly lower at 4 hours. In hepatectomized dogs, BCAA/AAA ratio fell gradually after total hepatectomy. The levels of amino acids except BCAA were higher than preoperative value. Increase of alanine was the most remarkable early after total hepatectomy. It was derived not only from the lack of glucose-alanine cycle but also from increased synthesis due to degradation of the BCAA in muscle.
晚期肝病患者表现出特征性的血浆氨基酸异常。这些患者肝移植后血浆氨基酸模式的反应尚不清楚。杂种犬接受了两种实验模型，即一种是在静脉-静脉旁路下进行全肝切除术，作为肝移植肝期的一种假设，另一种是脾切除术作为对照。在对照组中，支链氨基酸/芳香族氨基酸比值在手术期间逐渐升高。4小时时，蛋氨酸、甘氨酸和丙氨酸水平显著降低。在肝切除犬中，全肝切除后支链氨基酸/芳香族氨基酸比值逐渐下降。除支链氨基酸外的氨基酸水平高于术前值。全肝切除术后早期丙氨酸升高最为显著。这不仅源于葡萄糖-丙氨酸循环的缺乏，还源于肌肉中支链氨基酸降解导致的合成增加。
