Nagasue N, Kanashima R, Inokuchi K
Ann Chir Gynaecol. 1981;70(2):50-5.
Plasma amino acid concentrations were serially estimated after 82.5% resection of the liver in dogs. Slight to moderate decreases were found in valine, leucine, isoleucine, threonine and methionine concentrations for the first 12 hours. The first three branched chain amino acids thereafter increased up to 180%. Between 24 and 72 hours, threonine and methionine increased markedly in four surviving dogs but not in two which died in hepatic coma. Significant increases were found in phenylalanine and lysine concentrations but there was no substantial change in tryptophan levels throughout the experiment. Among the non essential amino acids, the most striking increase was seen in tyrosine and serine concentrations with their peak at 48 to 72 hours. Arginine and aspartate transiently decreased within 12 hours but most of other amino acids increased more or less during the observation. Although the molar ratios of the branched chain to the aromatic amino acids dropped dramatically, it was difficult to draw definitive remarks on the relationship between the molar ratio and the grade of hepatic coma in each animal. A further study is necessary to determine whether the correction of plasma amino acid alterations is beneficial or not following critical liver resection.
在对犬进行82.5%肝切除术后，连续测定血浆氨基酸浓度。在最初的12小时内，缬氨酸、亮氨酸、异亮氨酸、苏氨酸和蛋氨酸浓度出现轻度至中度下降。此后，前三种支链氨基酸增加了高达180%。在24至72小时之间，4只存活犬的苏氨酸和蛋氨酸显著增加，但2只死于肝昏迷的犬则没有。苯丙氨酸和赖氨酸浓度显著增加，但在整个实验过程中色氨酸水平没有实质性变化。在非必需氨基酸中，酪氨酸和丝氨酸浓度增加最为显著，在48至72小时达到峰值。精氨酸和天冬氨酸在12小时内短暂下降，但在观察期间大多数其他氨基酸或多或少有所增加。尽管支链氨基酸与芳香族氨基酸的摩尔比急剧下降，但很难就每只动物的摩尔比与肝昏迷程度之间的关系得出明确结论。有必要进一步研究在严重肝切除术后纠正血浆氨基酸改变是否有益。
