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有哪些药物对新冠病毒具有潜在疗效?

What are the drugs having potential against COVID-19?

作者信息

Kucukoglu Kaan, Faydalı Nagihan, Bul Dilek

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Selcuk University, Konya, Turkey.

出版信息

Med Chem Res. 2020;29(11):1935-1955. doi: 10.1007/s00044-020-02625-1. Epub 2020 Sep 10.

Abstract

A disease emerged in the city of Wuhan, Hubei Province, Central China in the last month of 2019. It was pneumonia caused by a newly emerged coronavirus called COVID-19, later. Coronaviruses are enveloped RNA viruses belong to the Betacoronavirus family and infected birds, humans, and other mammals. In March 2020, the World Health Organization declared the COVID-19 outbreak could be characterized as a global pandemic because the disease spread, and a large number of people were infected and died in many countries on different continents by virtue of this new virus. Now, intensive work is underway about the pathogenic mechanisms and epidemiological properties of COVID-19, and a great effort is made to develop effective specific therapeutic drugs, vaccines, and/or treatment strategies against these diseases. Herein, we have focused on all treatment options available against COVID-19 pneumonia in this text.

摘要

2019年最后一个月,一种疾病在中国中部湖北省武汉市出现。后来发现这是一种由新出现的冠状病毒COVID-19引起的肺炎。冠状病毒是有包膜的RNA病毒,属于β冠状病毒科,可感染鸟类、人类和其他哺乳动物。2020年3月,世界卫生组织宣布COVID-19疫情可被界定为全球大流行,因为该疾病出现了传播,凭借这种新病毒,不同大陆的许多国家有大量人员感染并死亡。目前,针对COVID-19的致病机制和流行病学特性正在开展深入研究,并且正在大力研发针对这些疾病的有效特效治疗药物、疫苗和/或治疗策略。在此,我们在本文中重点关注了针对COVID-19肺炎的所有可用治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5115/7481551/c71558162584/44_2020_2625_Fig1_HTML.jpg

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