Department of Ophthalmology, Shamir Medical Center (Formerly Assaf-Harofeh), Tzrifin, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Int Ophthalmol. 2021 Feb;41(2):433-440. doi: 10.1007/s10792-020-01592-1. Epub 2020 Sep 14.
Coronavirus disease 2019 (COVID-19) caused a global pandemic with millions infected worldwide. Little is known on the ocular involvement associated with the disease. The aim of this study was to assess the clinical and molecular ocular involvement among patients with confirmed COVID-19 admitted to a tertiary care facility.
Consecutive patients admitted to the COVID-19 Ward of the Shamir Medical Center in Israel during March and April, 2020 were included. The control group included patients negative for COVID-19 admitted during a similar period to a different ward. Patients were examined by trained Ophthalmologists. SARS-CoV-2 conjunctival swab samples were obtained.
Included were 48 patients, 16 with confirmed COVID-19 and 32 controls. Median patient age was 68.5 (interquartile range: 31.5, mean: 63 ± 21) years and 48% were male. Active conjunctival injection was present in three patients (19%) with COVID-19, compared to none in the controls (p = 0.034). Patients with COVID-19 were more likely to complain of foreign body sensation (31.3% vs 3.1%, p = 0.005) and redness of the eye (25% vs 0%, p = 0.003). Conjunctival injection was associated with loss of smell and taste (75% vs 7.7%, p = 0.018). Viral conjunctival swab tests all showed negative results for all three viral genes tested (E, N, and RdRp).
Among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was noted in one out of five cases, and was associated with loss of smell and taste. Conjunctival swabs for viral RNA were negative in patients with and without ocular involvement.
2019 年冠状病毒病（COVID-19）在全球范围内造成了大流行，全球数百万人感染。目前对于该疾病相关的眼部并发症知之甚少。本研究旨在评估在以色列一家三级保健机构住院的确诊 COVID-19 患者的临床和分子眼部受累情况。
纳入 2020 年 3 月至 4 月期间在以色列沙米尔医疗中心 COVID-19 病房住院的连续患者。对照组纳入在同一时期入住不同病房且 COVID-19 检测为阴性的患者。所有患者均由经过培训的眼科医生进行检查。采集 SARS-CoV-2 结膜拭子样本。
共纳入 48 例患者，其中 16 例确诊 COVID-19，32 例为对照组。中位患者年龄为 68.5（四分位距：31.5，平均：63±21）岁，48%为男性。3 例 COVID-19 患者存在活动性结膜充血（19%），而对照组无患者存在（p=0.034）。COVID-19 患者更有可能主诉异物感（31.3%比 3.1%，p=0.005）和眼红（25%比 0%，p=0.003）。结膜充血与嗅觉和味觉丧失相关（75%比 7.7%，p=0.018）。对所有 3 种病毒基因（E、N 和 RdRp）进行的病毒结膜拭子检测结果均为阴性。
在入住一家三级转诊中心的确诊 COVID-19 患者中，五分之一的患者出现活动性结膜充血，与嗅觉和味觉丧失相关。有和无眼部受累的患者的结膜拭子病毒 RNA 检测均为阴性。
