Suppr
超能文献

黏附侵袭性大肠杆菌(pathobiont adherent-invasive Escherichia coli)与炎症性肠病的流行情况：系统评价和荟萃分析。

Prevalence of the pathobiont adherent-invasive Escherichia coli and inflammatory bowel disease: a systematic review and meta-analysis.

机构信息

Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

J Gastroenterol Hepatol. 2021 Apr;36(4):852-863. doi: 10.1111/jgh.15260. Epub 2020 Sep 28.

DOI:10.1111/jgh.15260

PMID:32929762

Abstract

BACKGROUND AND AIM

Escherichia coli pathobionts and particularly the adherent-invasive E. coli (AIEC) may play a putative role in initiating and maintaining the inflammatory process in the intestinal tissues of inflammatory bowel disease (IBD) patients, by providing stimulatory factors that trigger gut immune system activation. The aim of this study is to conduct a systematic review and meta-analysis to determine the prevalence of AIEC among patients with Crohn's disease (CD) and ulcerative colitis (UC).

METHODS

Electronic databases were searched up to February 2020 for relevant publications reporting the prevalence of AIEC in IBD patients. The prevalence rate of AIEC among CD and UC patients, the odds ratio (OR) and 95% confidence interval (CI) were calculated compared to non-IBD controls.

RESULTS

The final dataset included 12 studies, all investigating AIEC isolates from ileal/colonic specimens. The OR for prevalence of AIEC in CD patients was 3.27 (95% CI 1.79-5.9) compared with non-IBD controls. The overall pooled prevalence of AIEC among CD patients was 29% (95% CI 0.17-0.45), whereas this prevalence was calculated to be 9% (95% CI 0.03-0.19) in controls. Moreover, the prevalence of AIEC in UC subjects was calculated 12% (95% CI 0.01-0.34), while AIEC showed a prevalence of 5% (95% CI 0.0-0.17) among the controls. The OR for prevalence of AIEC in UC patients was 2.82 (95% CI 1.11-7.14) compared with controls.

CONCLUSIONS

There is a substantial increase in the prevalence of AIEC in IBD patients compared with controls. This review supports the growing evidence that AIEC could be involved in both CD and UC pathogenesis.

摘要

背景与目的

肠致病性大肠杆菌（E. coli pathobionts），尤其是黏附侵袭性大肠杆菌（adherent-invasive E. coli，AIEC），可能通过提供刺激肠道免疫系统激活的刺激因子，在炎症性肠病（inflammatory bowel disease，IBD）患者的肠道组织中发挥起始和维持炎症过程的潜在作用。本研究旨在进行系统评价和荟萃分析，以确定 AIEC 在克罗恩病（Crohn's disease，CD）和溃疡性结肠炎（ulcerative colitis，UC）患者中的流行率。

方法

检索电子数据库，截至 2020 年 2 月，以获取报告 IBD 患者中 AIEC 流行率的相关文献。计算 AIEC 在 CD 和 UC 患者中的流行率、优势比（odds ratio，OR）和 95%置信区间（confidence interval，CI），并与非 IBD 对照组进行比较。

结果

最终数据集包括 12 项研究，均对来自回肠/结肠标本的 AIEC 分离株进行了研究。与非 IBD 对照组相比，CD 患者 AIEC 流行率的 OR 为 3.27（95%CI 1.79-5.9）。CD 患者 AIEC 总体合并流行率为 29%（95%CI 0.17-0.45），而对照组为 9%（95%CI 0.03-0.19）。此外，UC 患者 AIEC 的流行率计算为 12%（95%CI 0.01-0.34），而对照组中 AIEC 的流行率为 5%（95%CI 0.0-0.17）。与对照组相比，UC 患者 AIEC 流行率的 OR 为 2.82（95%CI 1.11-7.14）。