Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
Chem Commun (Camb). 2020 Oct 21;56(82):12351-12354. doi: 10.1039/d0cc05152g. Epub 2020 Sep 15.
Herein, gold@platinum (Au@Pt) bimetallic nanoparticles with high catalytic ability were in situ decorated onto a molybdenum disulfide (MoS) surface to obtain nanocomposites (MoS-Au@Pt) with high peroxidase-mimicking activity, which were used to construct a colorimetric sensor for cysteine (Cys) detection. Interestingly, this sensor can efficiently distinguish Cys from homocysteine (Hcy), glutathione (GSH) and 19 other amino acids with high sensitivity. As expected, the colorimetric sensor can determine the Cys content in Cys supplement tablets due to its high stability and repeatability. Finally, the detection mechanism was studied.
在此，通过将具有高催化能力的金@铂（Au@Pt）双金属纳米粒子原位修饰到二硫化钼（MoS）表面上，获得了具有高过氧化物酶模拟活性的纳米复合材料（MoS-Au@Pt），并将其用于构建用于半胱氨酸（Cys）检测的比色传感器。有趣的是，该传感器可以通过高灵敏度有效地将 Cys 与同型半胱氨酸（Hcy）、谷胱甘肽（GSH）和其他 19 种氨基酸区分开。不出所料，由于其高稳定性和可重复性，比色传感器可以测定 Cys 补充片剂中的 Cys 含量。最后，研究了检测机制。
