Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, Guangdong, 519000, China; School of Medicine, Jinan University, Guangzhou, Guangdong, 510632, China; Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong, 510632, China.
Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China.
Cancer Lett. 2020 Dec 28;495:211-223. doi: 10.1016/j.canlet.2020.09.009. Epub 2020 Sep 12.
Hypoxia is a hallmark of cancer. To cope with hypoxic conditions, tumor cells alter their transcriptional profiles mainly through hypoxia-inducible factors (HIFs) and epigenetic reprogramming. Hypoxia, in part through HIF-dependent mechanisms, influences the expression or activity of epigenetic regulators to control epigenetic reprogramming, including DNA methylation and histone modifications, which regulate hypoxia-responsive gene expression in cells. Conversely, epigenetic regulators and chromatin architecture can modulate the expression, stability, or transcriptional activity of HIF. Understanding the complex networks between HIFs, epigenetic regulators, and chromatin reprogramming in response to hypoxia will provide insight into the fundamental mechanism of transcriptional adaptation to hypoxia, and may help identify novel targets for future therapies. In this review, we will discuss the comprehensive relationship between HIFs, epigenetic regulators, and chromatin reprogramming under hypoxic conditions.
缺氧是癌症的一个标志。为了应对缺氧环境，肿瘤细胞主要通过缺氧诱导因子（HIFs）和表观遗传重编程来改变其转录谱。缺氧通过部分依赖 HIF 的机制，影响表观遗传调控因子的表达或活性，以控制表观遗传重编程，包括 DNA 甲基化和组蛋白修饰，从而调节细胞中缺氧反应性基因的表达。相反，表观遗传调控因子和染色质结构可以调节 HIF 的表达、稳定性或转录活性。了解 HIF、表观遗传调控因子和染色质重编程在缺氧反应中的复杂网络，将深入了解转录对缺氧适应的基本机制，并可能有助于确定未来治疗的新靶点。在这篇综述中，我们将讨论在缺氧条件下 HIF、表观遗传调控因子和染色质重编程之间的全面关系。
