Saxena Kritika, Srikrishnan Syamanthak, Celia-Terrassa Toni, Jolly Mohit Kumar
Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India.
Department of Biotechnology, Indian Institute of Technology, Kharagpur, India.
Cells Tissues Organs. 2022;211(2):183-192. doi: 10.1159/000511383. Epub 2020 Sep 15.
OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus playing an important role during cancer cell metastasis. Due to their central role in differentiation and maintenance of epithelial lineage, OVOL overexpression has been shown to be capable of reprogramming fibroblasts to epithelial cells. Here, we review the roles of OVOL-mediated epithelial differentiation across multiple contexts, including embryonic development, cancer progression, and cellular reprogramming.
OVOL蛋白（OVOL1和OVOL2）是果蝇OVO在脊椎动物中的同源物，是胚胎发育过程中肾脏、皮肤、乳腺上皮和睾丸等组织上皮谱系确定和分化的关键调节因子。OVOL可以抑制上皮-间质转化和/或促进间质-上皮转化。此外，它们还可以调节癌细胞的干性，从而在癌细胞转移过程中发挥重要作用。由于它们在上皮谱系的分化和维持中发挥核心作用，OVOL的过表达已被证明能够将成纤维细胞重编程为上皮细胞。在这里，我们综述了OVOL介导的上皮分化在多种情况下的作用，包括胚胎发育、癌症进展和细胞重编程。
