Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Trends Cell Biol. 2023 Oct;33(10):824-833. doi: 10.1016/j.tcb.2023.05.008. Epub 2023 Jun 17.
Ovo like zinc finger 2 (OVOL2) is an evolutionarily conserved regulator of epithelial lineage determination and differentiation during embryogenesis. OVOL2 binds to DNA using zinc-finger domains to suppress epithelial-mesenchymal transition (EMT), which is critical for tumor metastasis. However, recent studies have suggested some noncanonical roles of OVOL2 that do not rely on the DNA binding of zinc-finger domains or regulation of EMT. OVOL2 and EMT regulators have emerging roles in adipogenesis, thermogenesis, and lipid metabolism. Here, we review different roles of OVOL2 from embryo development to adult tissue homeostasis, and discuss how OVOL2 and other EMT regulators orchestrate a regulatory network to control energy homeostasis. Last, we propose potential applications of targeting OVOL2 to reduce human obesity.
卵黄蛋白原类似锌指蛋白 2（OVOL2）是胚胎发生过程中上皮谱系决定和分化的一种进化上保守的调控因子。OVOL2 使用锌指结构域与 DNA 结合，以抑制上皮-间充质转化（EMT），这对于肿瘤转移至关重要。然而，最近的研究表明，OVOL2 具有一些不依赖于锌指结构域的 DNA 结合或 EMT 调节的非典型作用。OVOL2 和 EMT 调节剂在脂肪生成、生热和脂质代谢中具有新兴作用。在这里，我们回顾了 OVOL2 从胚胎发育到成人组织稳态的不同作用，并讨论了 OVOL2 和其他 EMT 调节剂如何协调一个调控网络来控制能量稳态。最后，我们提出了靶向 OVOL2 以减少人类肥胖的潜在应用。
