Nguyen-Powanda Paulina, Robaire Bernard
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.
Department of Obstetrics and Gynecology, McGill University, Montreal, QC H4A 3J1, Canada.
Biology (Basel). 2020 Sep 11;9(9):282. doi: 10.3390/biology9090282.
With the delay of parenthood becoming more common, the age at which men father children is on the rise. While the effects of advanced maternal age have been well documented, only recently have studies started to focus on the impact of advanced paternal age (APA) in the context of male reproduction. As men age, the antioxidant defense system gradually becomes less efficient and elevated levels of reactive oxygen species (ROS) accumulate in spermatozoa; this can impair their functional and structural integrity. In this review, we present an overview of how oxidative stress is implicated in male reproductive aging by providing a summary of the sources and roles of ROS, the theories of aging, and the current animal and human studies that demonstrate the impacts of APA on the male germ line, the health of progeny and fertility, and how treatment with antioxidants may reverse these effects.
随着生育推迟变得越来越普遍，男性生育孩子的年龄在上升。虽然高龄产妇的影响已有充分记录，但直到最近研究才开始关注高龄父亲（APA）在男性生殖方面的影响。随着男性年龄增长，抗氧化防御系统逐渐效率降低，活性氧（ROS）水平升高并在精子中积累；这会损害精子的功能和结构完整性。在本综述中，我们通过总结ROS的来源和作用、衰老理论以及当前证明APA对雄性生殖细胞、后代健康和生育能力影响的动物和人体研究，概述氧化应激如何与男性生殖衰老相关，以及抗氧化剂治疗如何可能逆转这些影响。
