Acharya Dilaram, Lee Kwan, Lee Dong Seok, Lee Yun Sik, Moon Seong-Su
Department of Preventive Medicine, College of Medicine, Dongguk University, Gyeongju 38066, Korea.
Department of Community Medicine, Kathmandu University, Devdaha Medical College and Research Institute, Rupandehi 32900, Nepal.
Healthcare (Basel). 2020 Sep 13;8(3):338. doi: 10.3390/healthcare8030338.
Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.
研究证实，新冠肺炎患者中，糖尿病患者的死亡风险高于非糖尿病患者。然而，在韩国，关于住院的新冠肺炎糖尿病患者中，与死亡风险增加相关因素的数据驱动证据却很匮乏。本研究旨在确定韩国庆尚北道住院的2型糖尿病新冠肺炎患者的死亡率，并识别其死亡风险因素。在这项基于医院的横断面研究中，我们纳入了2020年2月18日至6月30日期间在韩国庆尚北道的两家三级医疗保健机构住院的324例确诊新冠肺炎患者。分析了人口统计学和临床数据以及实验室检查结果，并采用多因素logistic回归分析来识别新冠肺炎糖尿病患者的死亡风险因素。在这324例患者中，55例（16.97%）患有糖尿病。所有研究对象的平均年龄为55岁，糖尿病患者的平均年龄大于非糖尿病患者（69.8岁对51.9岁）。值得注意的是，糖尿病患者的死亡率要高得多（20.0%对4.8%）。多因素logistic回归分析显示，年龄较大（≥70岁）和血清乳酸脱氢酶（LDH）水平较高显著预示着住院的新冠肺炎糖尿病患者的死亡。我们的研究提醒，对于因新冠肺炎住院的糖尿病患者，尤其是70岁及以上的患者和血清LDH水平较高的患者，应给予更多关注，以降低死亡风险。
