Moghaddam Tabrizi Fatemeh, Rasmi Yousef, Hosseinzadeh Elyas, Rezaei Sakineh, Balvardi Mohadeseh, Kouchari Mohammad Reza, Ebrahimi Ghasem
Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Khoy University of Medical Sciences, Khoy, Iran.
EXCLI J. 2021 Feb 22;20:444-453. doi: 10.17179/excli2021-3403. eCollection 2021.
As a novel cause of pneumonia, coronavirus disease 2019 (COVID-19) has rapidly progressed worldwide. Previous studies have indicated COVID-19 patients with diabetes show higher mortality rates and more severe COVID-19 infection with an increased requirement for intensive care and hospital length of stay (LOS) compared to non-diabetic patients. The present study aimed to investigate the association of diabetes and COVID-19 outcome with severity of disease in hospitalized patients. The present case-control study included 268 patients diagnosed with COVID-19 who were hospitalized in Ayatollah Khoyi Hospital, Khoy, Iran. Diabetes was identified based on medical history and/or criteria of published documents. Out of 268 patients (median age of 59 years; 53.4 % male), 127 patients had diabetes (47 %). Diabetic patients had remarkably higher mortality rates (adjusted odds ratio, aOR: 3.36; confidence interval, CI: 1.17-9.66), requirement for invasive mechanical ventilation (IMV) (aOR: 4.59; CI: 1.38-15.25), and LOS (aOR: 1.13; CI: 1.06-1.24) compared to patients without diabetes. Inflammatory biomarkers including C-reactive protein (CRP), lactate dehydrogenase (LDH), and erythrocyte sedimentation rate (ESR) were increased in patients with diabetes compared to non-diabetic patients (P < 0.05 for all the comparisons). In hospitalized patients with COVID-19, diabetes was correlated with increased disease severity and mortality.
作为肺炎的一种新病因，2019冠状病毒病（COVID-19）已在全球迅速蔓延。先前的研究表明，与非糖尿病患者相比，患有糖尿病的COVID-19患者死亡率更高，COVID-19感染更严重，对重症监护的需求增加，住院时间延长。本研究旨在调查住院患者中糖尿病和COVID-19结局与疾病严重程度之间的关联。本病例对照研究纳入了268例在伊朗霍伊市阿亚图拉·霍伊医院住院的COVID-19确诊患者。根据病史和/或已发表文献的标准确定糖尿病。在268例患者（中位年龄59岁；53.4%为男性）中，127例患有糖尿病（47%）。与非糖尿病患者相比，糖尿病患者的死亡率显著更高（调整后的优势比，aOR：3.36；置信区间，CI：1.17-9.66），有创机械通气（IMV）需求（aOR：4.59；CI：1.38-15.25）以及住院时间（aOR：1.13；CI：1.06-1.24）。与非糖尿病患者相比，糖尿病患者的炎症生物标志物包括C反应蛋白（CRP）、乳酸脱氢酶（LDH）和红细胞沉降率（ESR）均升高（所有比较P<0.05）。在住院的COVID-19患者中，糖尿病与疾病严重程度增加和死亡率相关。
