Laboratory of Vascular Immunology, Institute of Life Sciences, Bhubaneswar, India.
Manipal Academy of Higher Education, Manipal, India.
Crit Rev Biochem Mol Biol. 2020 Dec;55(6):555-575. doi: 10.1080/10409238.2020.1819194. Epub 2020 Sep 16.
Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a pattern recognition receptor (PRR) and is expressed on cells of different origin performing different functions. RAGE ligation leads to the initiation of a cascade of signaling events and is implicated in diseases, such as inflammation, cancer, diabetes, vascular dysfunctions, retinopathy, and neurodegenerative diseases. Because of the significant involvement of RAGE in the progression of numerous diseases, RAGE signaling has been targeted through use of inhibitors and anti-RAGE antibodies as a treatment strategy and therapy. Here in this review, we have summarized the physical and physiological aspects of RAGE biology in mammalian system and the importance of targeting this molecule in the treatment of various RAGE mediated pathologies. Highlights Receptor for advanced glycation end products (RAGE) is a member of immunoglobulin superfamily of receptors and involved in many pathophysiological conditions. RAGE ligation with its ligands leads to initiation of distinct signaling cascades and activation of numerous transcription factors. Targeting RAGE signaling through inhibitors and anti-RAGE antibodies can be promising treatment strategy.
晚期糖基化终产物受体（RAGE）是细胞表面存在的一种免疫球蛋白样受体。RAGE 与一系列结构多样的配体结合，作为模式识别受体（PRR），并在具有不同功能的不同来源的细胞上表达。RAGE 的配体结合导致信号级联的启动，并与炎症、癌症、糖尿病、血管功能障碍、视网膜病变和神经退行性疾病等疾病有关。由于 RAGE 在许多疾病的进展中具有重要作用，因此已经通过使用抑制剂和抗 RAGE 抗体作为治疗策略和治疗方法来靶向 RAGE 信号。在这篇综述中，我们总结了哺乳动物系统中 RAGE 生物学的物理和生理方面，以及靶向该分子在治疗各种 RAGE 介导的病理学中的重要性。
亮点：
晚期糖基化终产物受体（RAGE）是免疫球蛋白超家族受体的一员，参与许多病理生理条件。
RAGE 与其配体的结合导致不同信号级联的启动和许多转录因子的激活。
通过抑制剂和抗 RAGE 抗体靶向 RAGE 信号可能是一种有前途的治疗策略。
