Okazaki K, Yamamoto Y, Nishimori I, Nishioka T, Kagiyama S, Tamura S, Sakamoto Y, Nakazawa Y, Morita M, Yamamoto Y
First Department of Internal Medicine, Kochi Medical School, Japan.
Am J Gastroenterol. 1988 Aug;83(8):820-6.
We endoscopically measured pressures of the pancreatic duct (PP) and the sphincter of Oddi (SO) in patients with alcoholic (ALCP, n = 10), gallstone-associated (GSCP, n = 7), and idiopathic chronic pancreatitis (ICP, n = 21), and in 20 controls. The PP was significantly higher in the patients with ALCP (55.7 +/- 28.9 mm Hg), GSCP (33.6 +/- 16.2 mm Hg), or ICP (44.5 +/- 25.8 mm Hg) than in the controls (16.2 +/- 8.7 mm Hg), but there was no significant difference between ALCP, GSCP, and ICP. There was no significant difference between control subjects and ICP in the motility of SO. In ICP, there was no correlation between the PP and the motility of SO. In ALCP and GSCP, the frequencies of the papillary sphincter waves were significantly higher than in normal subjects, and there were correlations between the PP and the motility of SO. These data suggest that increased pancreatic ductal pressure in GSCP with papillitis or ALCP may be due in part to papillary dysfunction, but not in ICP.
我们通过内镜测量了酒精性慢性胰腺炎患者（ALCP，n = 10）、胆石相关性慢性胰腺炎患者（GSCP，n = 7）、特发性慢性胰腺炎患者（ICP，n = 21）以及20名对照者的胰管压力（PP）和Oddi括约肌压力（SO）。ALCP患者（55.7 +/- 28.9 mmHg）、GSCP患者（33.6 +/- 16.2 mmHg）或ICP患者（44.5 +/- 25.8 mmHg）的PP显著高于对照者（16.2 +/- 8.7 mmHg），但ALCP、GSCP和ICP之间无显著差异。对照者与ICP患者在SO的运动功能方面无显著差异。在ICP患者中，PP与SO的运动功能之间无相关性。在ALCP和GSCP患者中，乳头括约肌波的频率显著高于正常受试者，且PP与SO的运动功能之间存在相关性。这些数据表明，伴有乳头炎的GSCP或ALCP患者胰管压力升高可能部分归因于乳头功能障碍，但ICP患者并非如此。
