Novis B H, Bornman P C, Girdwood A W, Marks I N
Dig Dis Sci. 1985 Mar;30(3):225-8. doi: 10.1007/BF01347888.
A possible mechanism for pain in alcohol-induced chronic pancreatitis is increased pancreatic duct pressure. A study has been done to compare sphincter of Oddi and pancreatic duct pressures in normal controls and patients with alcohol-induced chronic pancreatitis who had recently had pain or who were pain-free. Pressures were measured in the sphincter of Oddi in 10 controls and 33 patients, in the pancreatic duct in six controls and 15 patients, and in the common bile duct in four controls and five patients during station pull-through at the time of an endoscopic retrograde cholangiopancreatogram. There was no significant difference in the mean pressures in the pancreatic duct, sphincter of Oddi (basal and phasic), and frequency of papillary contraction when comparing patients with alcoholic pancreatitis and controls. There was also no difference between patients with or without pain and patients with or without strictures. This study has not confirmed the hypothesis that increased pancreatic duct pressures may be incriminated as a possible mechanism of pain in alcoholic-induced chronic pancreatitis.
酒精性慢性胰腺炎疼痛的一种可能机制是胰管压力升高。已开展一项研究，比较正常对照组以及近期有疼痛或无疼痛的酒精性慢性胰腺炎患者的Oddi括约肌和胰管压力。在内镜逆行胰胆管造影术进行站拉操作时，对10名对照组和33名患者测量Oddi括约肌压力，对6名对照组和15名患者测量胰管压力，对4名对照组和5名患者测量胆总管压力。比较酒精性胰腺炎患者和对照组时，胰管、Oddi括约肌（基础和相位）的平均压力以及乳头收缩频率无显著差异。有疼痛与无疼痛的患者之间以及有狭窄与无狭窄的患者之间也无差异。这项研究未证实胰管压力升高可能是酒精性慢性胰腺炎疼痛的一种可能机制这一假说。
