Okazaki K, Yamamoto Y, Kagiyama S, Tamura S, Sakamoto Y, Morita M, Yamamoto Y
1st Department of Internal Medicine, Kochi Medical School, Japan.
Int J Pancreatol. 1988 Dec;3(6):457-68. doi: 10.1007/BF02788204.
To determine the significance of manometric pressure of the pancreatic duct in patients with alcoholic and idiopathic chronic pancreatitis, we used a microtransducer inserted through a duodenoscope to measure pressures in the papillary sphincter zone and pancreatic main duct in 20 control subjects and 31 patients with chronic pancreatitis without papillary stenosis including 10 cases of alcoholic chronic pancreatitis (ALCP) and 21 cases of idiopathic chronic pancreatitis (ICP). The pancreatic main ductal pressure was significantly higher in the patients with ALCP (55.7 +/- 28.9 mm Hg) or ICP (44.5 +/- 25.8 mm Hg) than in the controls (16.2 +/- 8.7 mm Hg), but there was no significant difference between ALCP and ICP. There was no significant difference between control subjects and ICP in the motility of the sphincter of Oddi. In ICP there were no correlationships between pancreatic ductal pressure and the motility of papillary sphincter zone. In ALCP, the frequency of the papillary sphincter waves was significantly higher than in normal subjects and there was a correlation between the pancreatic ductal pressure and the motility of the papillary sphincter zone. These data suggest that increased pancreatic ductal pressure in ALCP may be in part due to papillary dysfunction, but not in ICP.
为了确定酒精性和特发性慢性胰腺炎患者胰管测压的意义，我们使用微传感器通过十二指肠镜测量了20名对照者以及31例无乳头狭窄的慢性胰腺炎患者（包括10例酒精性慢性胰腺炎（ALCP）和21例特发性慢性胰腺炎（ICP））的乳头括约肌区和胰主胰管压力。ALCP患者（55.7±28.9 mmHg）或ICP患者（44.5±25.8 mmHg）的胰主胰管压力显著高于对照组（16.2±8.7 mmHg），但ALCP和ICP之间无显著差异。对照组与ICP在Oddi括约肌运动方面无显著差异。在ICP中，胰管压力与乳头括约肌区运动之间无相关性。在ALCP中，乳头括约肌波的频率显著高于正常受试者，且胰管压力与乳头括约肌区运动之间存在相关性。这些数据表明，ALCP中胰管压力升高可能部分归因于乳头功能障碍，但ICP并非如此。
