Levitt J J, Tsuang M T
Psychiatry Service, Brockton-West Roxbury VA Medical Center, MA 02401.
Am J Psychiatry. 1988 Aug;145(8):926-36. doi: 10.1176/ajp.145.8.926.
Until the 1970s, schizophrenia tended to be broadly defined in the United States, and the diagnosis subsumed patients who had affective as well as schizophrenic symptoms. With the introduction of lithium, however, manic-depressive illness became susceptible to treatment and gained attractiveness as a diagnosis. The ambiguous position of patients with schizoaffective disorder became clear. Cross-sectionally they were seen to resemble schizophrenic patients, but longitudinally they were more akin to patients with affective disorder. Numerous studies have attempted to establish that they are diagnostically distinct, but without clear results. The authors suggest that schizoaffective disorder is heterogeneous and that its treatment should be determined by specific indices as to its subtype.
直到20世纪70年代，精神分裂症在美国往往被宽泛地定义，该诊断涵盖了既有情感症状又有精神分裂症症状的患者。然而，随着锂盐的引入，躁郁症变得易于治疗，并作为一种诊断更具吸引力。精神分裂症性情感障碍患者的模糊地位变得清晰起来。从横断面看，他们类似于精神分裂症患者，但从纵向看，他们更类似于情感障碍患者。众多研究试图确定它们在诊断上是不同的，但没有明确结果。作者们认为，精神分裂症性情感障碍是异质性的，其治疗应根据其亚型的具体指标来确定。
