Meltzer H Y
Schizophr Bull. 1984;10(1):11-3. doi: 10.1093/schbul/10.1.11.
Because of the continued controversy about the nature of the schizoaffective disorders and their relationships to schizophrenia and the affective disorders, a thorough review of the concept, genetics, treatment, outcome, and biological aspects of the schizoaffective disorders in relationship to schizophrenia and the affective disorders appears timely. The use of explicit criteria for schizoaffective disorders, such as those provided by the Research Diagnostic Criteria, permits clinical investigators to continue the inquiry into these disorders. Current evidence appears most consistent with the idea that schizoaffective disorder is usually a variant of affective psychosis and sometimes a variant of schizophrenia. However, the possibility that an interacting group of biological vulnerabilities, environmental insults, and ensuing psychological reactions produces the spectrum of clinical states from "pure" schizophrenia to "pure" affective psychosis with schizoaffective disorder as a genuine mixed state needs further investigation. Dimensional diagnostic systems rather than categorical ones may be of value for many clinical and research purposes.
由于关于分裂情感性障碍的本质及其与精神分裂症和情感障碍的关系一直存在争议，因此，及时对分裂情感性障碍在与精神分裂症和情感障碍相关方面的概念、遗传学、治疗、转归及生物学特征进行全面回顾显得很有必要。使用明确的分裂情感性障碍诊断标准，如研究诊断标准所提供的那些标准，可使临床研究人员继续对这些障碍展开探究。目前的证据似乎最支持这样一种观点，即分裂情感性障碍通常是情感性精神病的一种变体，有时也是精神分裂症的一种变体。然而，一组相互作用的生物学易感性、环境损害及随之产生的心理反应导致从“纯粹”精神分裂症到“纯粹”情感性精神病并以分裂情感性障碍作为一种真正混合状态的一系列临床状态，这种可能性尚需进一步研究。对于许多临床和研究目的而言，维度诊断系统而非类别诊断系统可能更有价值。
