Harrow M, Grossman L S, Herbener E S, Davies E W
Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.
Br J Psychiatry. 2000 Nov;177:421-6. doi: 10.1192/bjp.177.5.421.
It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders.
To provide longitudinal data on clinical course and outcome in schizoaffective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications.
A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic disorders and depression were assessed at hospitalisation and then followed up four times over 10 years.
At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05).
Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.
分裂情感性障碍的预后与精神分裂症或情感障碍更为相似，目前尚不清楚。
提供关于分裂情感性障碍与精神分裂症和情感障碍的临床病程及预后的纵向数据，并确定心境不一致的精神病性症状是否具有不良预后意义。
共有210例分裂情感性障碍、精神分裂症、双相躁狂障碍和抑郁症患者在住院时接受评估，然后在10年中进行了4次随访。
在所有4次随访中，分裂情感性障碍患者中结局始终较差的人数少于精神分裂症患者。在首次住院期间出现心境不一致的精神病性症状的患者，其随后的结局明显较差（P < 0.05）。
分裂情感性障碍的预后优于精神分裂症，比伴有精神病性症状的情感障碍的预后差。心境不一致的精神病性症状具有不良预后意义。这些结果符合分裂情感性障碍病程的症状维度观点。
