Darre Tchin, Tchaou Mazamaesso, Djiwa Toukilnan, Simgban Panakinao, Amavi Ayi Kossi, N'Timon Bidamin, Amadou Abdoulatif, Bombonne Mayi, Sama Bagassam, Amégbor Koffi, Napo-Koura Gado
Department of Pathology, University Teaching Hospital of Lomé, Togo.
Department of Imaging, University Teaching Hospital of Lomé and Kara, Togo.
Int J Breast Cancer. 2020 Aug 31;2020:3056067. doi: 10.1155/2020/3056067. eCollection 2020.
Breast cancer in men is a rare condition, often diagnosed late. The purpose of this study was to describe its epidemiological, histopathological, and radiographic aspects in Togo.
This was a descriptive retrospective study on cases of breast cancer in humans diagnosed histologically at the Laboratory of Anatomy Pathological and Imagery of the University Hospital in Lomé, over a period of 25 years (1995 to 2019). The parameters studied were epidemiological, anatomopathological, and imaging.
Eighty-two (82) cases were diagnosed, an annual frequency of 3.28 cases. The mean age was 45 ± 2.5 years; the range was 27-63 years. The family history of 47 patients (57.32%) was known. Carcinomas represented the predominant histological group with predominantly nonspecific invasive carcinoma (87.5%). These cancers were diagnosed at late stages (75.71% grade II). They were mainly of luminal B profile (38.75%) and associated with mutations of the BRCA2 and BRCA1 genes in 14.63% of the cases. The lesions were classified ACR 5 in 61.5% (11/18). Two cases of breast angiosarcoma were diagnosed by the identification of CD31 markers and factor VIII in immunohistochemistry. Hormone therapy such as tamoxifen was prescribed in all luminal patients (43 patients). Radiotherapy was administered to 15 patients (18.3%), with acute toxicity in 20% of the cases. After a median follow-up of 36 months, the evolution was complete remission in 27 patients (32.93%).
Breast cancer in men is rare, often diagnosed late with a poor prognosis.
男性乳腺癌是一种罕见疾病，通常诊断较晚。本研究的目的是描述其在多哥的流行病学、组织病理学和影像学特征。
这是一项描述性回顾性研究，研究对象为在洛美大学医院解剖病理与影像学实验室经组织学诊断的人类乳腺癌病例，研究时间跨度为25年（1995年至2019年）。研究的参数包括流行病学、解剖病理学和影像学。
共诊断出82例病例，年发病率为3.28例。平均年龄为45±2.5岁；年龄范围为27 - 63岁。47例患者（57.32%）有家族病史。癌是主要的组织学类型，以非特异性浸润性癌为主（87.5%）。这些癌症多在晚期诊断（75.71%为II级）。它们主要为管腔B型（38.75%），14.63%的病例与BRCA2和BRCA1基因的突变有关。61.5%（11/18）的病变被分类为ACR 5级。通过免疫组织化学鉴定CD31标志物和因子VIII诊断出2例乳腺血管肉瘤。所有管腔型患者（43例）均接受了他莫昔芬等激素治疗。15例患者（18.3%）接受了放疗，20%的病例出现急性毒性反应。中位随访36个月后，27例患者（32.93%）病情完全缓解。
男性乳腺癌罕见，通常诊断较晚，预后较差。
