Hendriks Erwin, Voogt Lennard, Lenoir Dorine, Coppieters Iris, Ickmans Kelly
Pain in Motion research group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.
Rehabilitation Centre Drechtsteden/Haaglanden, Dordrecht, the Netherlands.
Pain Med. 2020 Dec 25;21(12):3401-3412. doi: 10.1093/pm/pnaa276.
Central sensitization is present in different pain conditions, including chronic whiplash-associated disorders. In the absence of a gold standard method of assessment to determine the presence of central sensitization, quantitative sensory testing is currently understood as an optimal proxy. Laboratory sensory testing is, however, not feasible in clinical practice, and the Central Sensitization Inventory was developed as an alternative. The aim of the current study was to evaluate the convergent validity of the Central Sensitization Inventory in chronic whiplash-associated patients by determining the association between the Central Sensitization Inventory and quantitative sensory testing, pain intensity, fatigue, and psychosocial factors.
A total of 125 chronic whiplash-associated patients completed multiple questionnaires and were subjected to pressure pain thresholds and temporal summation.
. The Central Sensitization Inventory showed a strong association with constructs of general psychopathology, anxiety, distress, depression, and somatization in chronic whiplash-associated disorders. Moderate correlations were found with fatigue and intrusive and avoidant phenomena after a variety of traumatic events. No significant association was found between the Central Sensitization Inventory and pressure pain thresholds and temporal summation, nor between the Central Sensitization Inventory and other pain measurements.
Overall, we found that the Central Sensitization Inventory is better in identifying the psychosocial factors related to central sensitization in chronic whiplash-associated disorders than the central nervous system adaptations. Thus, the convergent validity of the Central Sensitization Inventory appears to be only partially present in chronic whiplash-associated disorders.
中枢敏化存在于不同的疼痛状况中，包括慢性挥鞭样损伤相关疾病。在缺乏用于确定中枢敏化存在的金标准评估方法的情况下，定量感觉测试目前被认为是最佳替代方法。然而，实验室感觉测试在临床实践中不可行，因此开发了中枢敏化量表作为替代。本研究的目的是通过确定中枢敏化量表与定量感觉测试、疼痛强度、疲劳及心理社会因素之间的关联，评估中枢敏化量表在慢性挥鞭样损伤相关患者中的收敛效度。
共有125例慢性挥鞭样损伤相关患者完成了多项问卷，并接受了压痛阈值和时间总和测试。
中枢敏化量表与慢性挥鞭样损伤相关疾病中的一般精神病理学、焦虑、痛苦、抑郁和躯体化结构密切相关。发现与各种创伤事件后的疲劳以及侵入性和回避性现象存在中度相关性。未发现中枢敏化量表与压痛阈值和时间总和之间存在显著关联，也未发现中枢敏化量表与其他疼痛测量指标之间存在显著关联。
总体而言，我们发现中枢敏化量表在识别慢性挥鞭样损伤相关疾病中与中枢敏化相关的心理社会因素方面比中枢神经系统适应性更好。因此，中枢敏化量表的收敛效度在慢性挥鞭样损伤相关疾病中似乎仅部分存在。
