Cai J, Huang L, Wang L J, Zheng M H, Liu H
Department of Parasitology, Zunyi Medical College, Zunyi 563000, China.
Guizhou Key Laboratory of Gene Detection and Treatment, Zunyi Medical College, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Feb 24;32(4):432-435. doi: 10.16250/j.32.1374.2019252.
Macrophages are important members of innate immunity and play an extremely important role in the host defense against pathogenic infections, tumors, and allergic diseases. Macrophages have a high degree of plasticity, and may be polarized into classical activated macrophages (M1 macrophages) and alternative activated macrophages (M2 macrophages) under the stimulation of different environments. M1 macrophages are found to promote inflammatory responses, which facilitates the clearance of pathogens, while M2 macrophages may inhibit inflammatory responses, which facilitates the survival and reproduction of pathogens. This review summarizes the role of macrophage polarization in parasitic infections, so as to provide insights into the prevention and treatment of parasitic diseases.
巨噬细胞是固有免疫的重要成员，在宿主抵御病原感染、肿瘤和过敏性疾病中发挥着极其重要的作用。巨噬细胞具有高度的可塑性，在不同环境刺激下可能极化为经典活化巨噬细胞（M1巨噬细胞）和替代性活化巨噬细胞（M2巨噬细胞）。研究发现，M1巨噬细胞可促进炎症反应，有利于病原体的清除，而M2巨噬细胞可能抑制炎症反应，有利于病原体的生存和繁殖。本文综述了巨噬细胞极化在寄生虫感染中的作用，以期为寄生虫病的防治提供思路。
