Wuchang Hospital Affiliated with Wuhan University of Science and Technology, Wuhan, 430063, China.
Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, China.
Exp Parasitol. 2024 Jan;256:108649. doi: 10.1016/j.exppara.2023.108649. Epub 2023 Oct 31.
Type 1 diabetes mellitus is a chronic disease caused by the destruction of pancreatic beta cells. Based on the hygiene hypothesis, a growing body of evidence suggests a negative association between parasitic infections and diabetes in humans and animal models. The mechanism of parasite-mediated prevention of type 1 diabetes mellitus may be related to the adaptive and innate immune systems. Macrophage polarization is a new paradigm for the treatment of type 1 diabetes mellitus, and different host macrophage subsets play various roles during parasite infection. Proinflammatory cytokines are released by M1 macrophages, which are important in the development of type 1 diabetes mellitus. Parasite-activated M2 macrophages prevent the development of type 1 diabetes mellitus and can influence the development of adaptive immune responses through several mechanisms, including Th2 cells and regulatory T cells. Here, we review the role and mechanism of macrophage polarization in parasitic protection against type 1 diabetes mellitus.
1 型糖尿病是一种由胰腺β细胞破坏引起的慢性疾病。基于卫生假说，越来越多的证据表明寄生虫感染与人类和动物模型中的糖尿病之间存在负相关。寄生虫介导的 1 型糖尿病预防的机制可能与适应性和先天免疫系统有关。巨噬细胞极化是 1 型糖尿病治疗的一个新范例，不同的宿主巨噬细胞亚群在寄生虫感染过程中发挥不同的作用。M1 巨噬细胞释放促炎细胞因子，这在 1 型糖尿病的发展中很重要。寄生虫激活的 M2 巨噬细胞可预防 1 型糖尿病的发生，并可通过多种机制影响适应性免疫反应的发展，包括 Th2 细胞和调节性 T 细胞。在这里，我们综述了巨噬细胞极化在寄生虫保护 1 型糖尿病中的作用和机制。
