基于人群的干预与基于遗传的干预在体重、BMI 和身体成分方面的变化：NOW 试验。

Change in Weight, BMI, and Body Composition in a Population-Based Intervention Versus Genetic-Based Intervention: The NOW Trial.

机构信息

Graduate Program in Health and Rehabilitation Sciences, The University of Western Ontario, London, Ontario, Canada.

The East Elgin Family Health Team, Aylmer, Ontario, Canada.

出版信息

Obesity (Silver Spring). 2020 Aug;28(8):1419-1427. doi: 10.1002/oby.22880.

DOI:10.1002/oby.22880

PMID:32935529

Abstract

OBJECTIVE

The aim of this study was to compare changes in body fat percentage (BFP), weight, and BMI between a standard intervention and a nutrigenomics intervention.

METHODS

The Nutrigenomics, Overweight/Obesity and Weight Management (NOW) trial is a parallel-group, pragmatic, randomized controlled clinical trial incorporated into the Group Lifestyle Balance (GLB) Program. Statistical analyses included two-way ANOVA and split-plot ANOVA. Inclusion criteria consisted of: BMI ≥ 25.0 kg/m , ≥18 years of age, English speaking, willing to undergo genetic testing, having internet access, and not seeing another health care provider for weight-loss advice outside of the study. Pregnancy and lactation were exclusion criteria. GLB groups were randomly assigned 1 to 1 (N = 140) so that participants received either the standard 12-month GLB program or a modified 12-month program (GLB plus nutrigenomics), which included the provision of nutrigenomics information and advice for weight management. The primary outcome was percent change in BFP. Secondary outcomes were change in weight and BMI.

RESULTS

The GLB plus nutrigenomics group experienced significantly (P < 0.05) greater reductions in percent and absolute BFP at the 3-month follow-up and percent BFP at the 6-month follow-up compared with the standard GLB group.

CONCLUSIONS

The nutrigenomics intervention used in the NOW trial can optimize change in body composition up to 6 months.

摘要

目的

本研究旨在比较标准干预和营养基因组学干预之间体脂百分比（BFP）、体重和 BMI 的变化。

方法

营养基因组学、超重/肥胖和体重管理（NOW）试验是一项平行组、实用、随机对照临床试验，纳入了群体生活方式平衡（GLB）计划。统计分析包括双向方差分析和分割-区组方差分析。纳入标准包括：BMI≥25.0kg/m2，年龄≥18 岁，英语流利，愿意接受基因检测，有互联网接入，并且在研究之外不向其他医疗保健提供者寻求减肥建议。妊娠和哺乳期除外。GLB 组按 1:1 随机分组（N=140），使参与者接受标准的 12 个月 GLB 方案或改良的 12 个月 GLB 方案（GLB 加营养基因组学），其中包括提供营养基因组学信息和体重管理建议。主要结局是 BFP 的百分比变化。次要结局是体重和 BMI 的变化。