人乳寡糖与西班牙裔婴儿头 6 个月体重增长。
Human Milk Oligosaccharides and Hispanic Infant Weight Gain in the First 6 Months.
机构信息
Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Integrative Physiology, University of Colorado, Boulder, Boulder, Colorado, USA.
出版信息
Obesity (Silver Spring). 2020 Aug;28(8):1519-1525. doi: 10.1002/oby.22884.
OBJECTIVE
The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain at 6 months and whether associations varied by HMO secretor status.
METHODS
Participants were 157 Hispanic mother-infant pairs. Human milk samples were collected at 1 month. Nineteen individual HMOs were analyzed using high-performance liquid chromatography, and secretor status was determined by the presence of 2'-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months. Path analysis was used to test effects of HMO composition on infant weight gain, adjusting for maternal age, prepregnancy BMI, and infant age, sex, and birth weight.
RESULTS
In the total sample, higher LNFPII predicted lower infant weight gain (g = -4.1, P = 0.004); this was observed in both nonsecretor (g = -3.0, P = 0.006) and secretor groups (g = -4.7, P = 0.014). In the nonsecretor group, higher lacto-N-neotetraose (g = 7.6, P = 0.011) and disialyllacto-N-tetraose (g = 14.3, P = 0.002) predicted higher infant weight gain. There were no other associations in the secretor group.
CONCLUSIONS
Our data suggest that higher LNFPII in human milk may decrease obesity risk across all infants, whereas higher lacto-N-neotetraose and disialyllacto-N-tetraose may increase obesity risk in infants of nonsecretors only.
目的
本研究旨在确定 1 月龄时人乳寡糖（HMOs）是否可预测 6 月龄时婴儿体重增长情况，以及这些关联是否因 HMO 分泌状态而异。
方法
参与者为 157 对西班牙裔母婴对。在 1 月龄时收集人乳样本。使用高效液相色谱法分析了 19 种 HMO，通过 2'-岩藻糖基乳糖或乳-N-岩藻五糖（LNFP）I 的存在来确定分泌状态。在 1 月龄和 6 月龄时测量婴儿体重。采用路径分析检验 HMO 组成对婴儿体重增长的影响，调整了母亲年龄、孕前 BMI 以及婴儿年龄、性别和出生体重。
结果
在总样本中，较高的 LNFPII 预示着婴儿体重增长较低（g=-4.1，P=0.004）；在非分泌者（g=-3.0，P=0.006）和分泌者组（g=-4.7，P=0.014）中均观察到这种情况。在非分泌者组中，较高的乳-N-新四糖（g=7.6，P=0.011）和二唾液酸乳糖-N-四糖（g=14.3，P=0.002）预示着婴儿体重增长较高。在分泌者组中没有其他关联。
结论
我们的数据表明，母乳中较高的 LNFPII 可能会降低所有婴儿的肥胖风险，而较高的乳-N-新四糖和二唾液酸乳糖-N-四糖可能会增加非分泌者婴儿的肥胖风险。
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