产妇血压介导了产后早期产妇肥胖与婴儿体重增加之间的关联。
Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum.
作者信息
Berger Paige K, Plows Jasmine F, Jones Roshonda B, Pollock Norman K, Alderete Tanya L, Ryoo Ji Hoon, Goran Michael I
机构信息
Department of Pediatrics, Children's Hospital Los Angeles, The University of Southern California, Los Angeles, CA, USA.
Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA, USA.
出版信息
Pediatr Obes. 2019 Nov;14(11):e12560. doi: 10.1111/ijpo.12560. Epub 2019 Jul 11.
BACKGROUND
It is unknown to what extent higher maternal blood pressure (BP) in early postpartum impacts the relationship between higher maternal weight status and greater infant weight gain in early postpartum.
OBJECTIVE
To evaluate the mediating role of higher maternal BP at 1 month postpartum on the association between higher maternal weight status at 1 month postpartum and greater infant weight gain over 6 months postpartum.
METHODS
Participants were 169 Hispanic mother-infant pairs. Maternal body mass index (BMI) and BP were assessed at 1 month postpartum. Infant weight was measured at 1 and 6 months postpartum to calculate weight-for-age z scores (WAZ). Multiple linear regression models were used for prediction, and Sobel test was used to determine mediation.
RESULTS
Controlling for maternal pre-pregnancy BMI, age, delivery mode, infant sex, and infant birth weight revealed that both maternal BMI (β = .29) and BP (β = .32) predicted infant WAZ gain (both P ≤ .03). However, the relationship between infant WAZ gain and maternal BMI was no longer significant after further adjustment for maternal BP, which remained significant (P < .05). Maternal BP explained 23.6% (Sobel T = 2.01) of the association between maternal BMI at 1 month and infant WAZ gain over 6 months.
CONCLUSION
Our data suggest that higher maternal weight status at 1 month postpartum is related to greater infant weight gain over 6 months postpartum, and this relationship is mediated by higher maternal BP at 1 month postpartum.
背景
产后早期较高的母亲血压对产后早期较高的母亲体重状况与更大的婴儿体重增加之间关系的影响程度尚不清楚。
目的
评估产后1个月时较高的母亲血压在产后1个月时较高的母亲体重状况与产后6个月内更大的婴儿体重增加之间关联中的中介作用。
方法
研究对象为169对西班牙裔母婴。在产后1个月时评估母亲的体重指数（BMI）和血压。在产后1个月和6个月时测量婴儿体重，以计算年龄别体重Z评分（WAZ）。使用多元线性回归模型进行预测，并使用Sobel检验来确定中介作用。
结果
在控制母亲孕前BMI、年龄、分娩方式、婴儿性别和婴儿出生体重后发现，母亲BMI（β = 0.29）和血压（β = 0.32）均能预测婴儿WAZ增加（P均≤0.03）。然而，在进一步调整母亲血压后，婴儿WAZ增加与母亲BMI之间的关系不再显著，而母亲血压仍具有显著性（P < 0.05）。母亲血压解释了产后1个月时母亲BMI与产后6个月内婴儿WAZ增加之间关联的23.6%（Sobel T = 2.01）。
结论
我们的数据表明，产后1个月时较高的母亲体重状况与产后6个月内更大的婴儿体重增加有关，并且这种关系由产后1个月时较高的母亲血压介导。
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