1 月龄和 6 月龄西班牙裔婴儿人乳寡糖（HMO）与饮食行为的相关性研究。

Associations between human milk oligosaccharides (HMOs) and eating behaviour in Hispanic infants at 1 and 6 months of age.

机构信息

Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.

Department of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, California, USA.

出版信息

Pediatr Obes. 2020 Dec;15(12):e12686. doi: 10.1111/ijpo.12686. Epub 2020 Jul 3.

DOI:10.1111/ijpo.12686

PMID:32621402

Abstract

BACKGROUND

Human milk oligosaccharides (HMOs) are naturally occurring glycans in human breast milk that act as prebiotics in the infant gut. Prebiotics have been demonstrated to suppress appetite in both adults and children. Therefore, HMOs may affect infant eating behaviour.

OBJECTIVE

To determine if HMOs in breast milk are associated with eating behaviour in Hispanic infants.

METHODS

Cross-sectional analysis of a prospective cohort of Hispanic mother-infant dyads (1-month, n = 157; 6-months, n = 69). Breast milk samples were screened for 19 HMOs using high pressure liquid chromatography, and eating behaviour was assessed using the Baby Eating Behaviour Questionnaire (BEBQ). We conducted multiple linear regressions to examine associations between HMOs and BEBQ scores, adjusted for maternal pre-pregnancy BMI, infant sex, birthweight, delivery mode and number of breastfeedings per day. We stratified by HMO secretor status-a genetic determinant of the types of HMOs produced.

RESULTS

At 1 month, LNnT (lacto-N-neotetraose; P = .04) was negatively associated with food responsiveness in the total sample, while DFLNT (difucosyllacto-N-tetrose; P = .03) and DSLNT (disialyl-LNT; P = .04) were negatively associated with food responsiveness in secretors only. At 6 months, LSTc (sialyllacto-N-tetraose c; P = .01), FLNH (fucosyllacto-N-hexaose; P = .03), LNH (lacto-N-hexaose; P = .006) and DSLNH (disialyllacto-N-hexaose; P = .05) were positively associated with food responsiveness in both the total sample and secretors only.

CONCLUSIONS

We found several HMOs that were both positively and negatively associated with infant food responsiveness, which is a measure of drive to eat.

摘要

背景

人乳寡糖（HMOs）是母乳中天然存在的糖，在婴儿肠道中作为益生元。已证实益生元可抑制成人和儿童的食欲。因此，HMOs 可能会影响婴儿的进食行为。

目的

确定母乳中的 HMOs 是否与西班牙裔婴儿的进食行为有关。

方法

对西班牙裔母婴对（1 个月，n=157；6 个月，n=69）的前瞻性队列进行横断面分析。使用高效液相色谱法筛选母乳样本中的 19 种 HMOs，并使用婴儿进食行为问卷（BEBQ）评估进食行为。我们进行了多次线性回归分析，以检验 HMOs 与 BEBQ 评分之间的关联，调整了母亲孕前 BMI、婴儿性别、出生体重、分娩方式和每天母乳喂养次数。我们根据 HMO 分泌状态进行分层-这是产生 HMO 类型的遗传决定因素。

结果

在 1 个月时，LNnT（乳-N-新四糖；P=0.04）与总样本中的食物反应性呈负相关，而 DFLNT（二岩藻基乳糖-N-四糖；P=0.03）和 DSLNT（二唾液酸基-LNT；P=0.04）与分泌者中食物反应性呈负相关。在 6 个月时，LSTc（唾液酸乳糖-N-四糖 c；P=0.01）、FLNH（岩藻糖基乳糖-N-六糖；P=0.03）、LNH（乳糖-N-六糖；P=0.006）和 DSLNH（二唾液酸基乳糖-N-六糖；P=0.05）与总样本和分泌者中食物反应性呈正相关。