猪圆环病毒样病毒 P1 衣壳蛋白 163 位氨基酸缺失突变株的全基因组序列。
Complete genome sequences of porcine circovirus-like virus P1 mutants with 163 amino acids in the capsid protein.
机构信息
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences·Key Laboratory of Animal Diseases, Diagnostics, and Immunology, Ministry of Agriculture·Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Nanjing, China.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infections Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
出版信息
Arch Virol. 2020 Dec;165(12):2985-2987. doi: 10.1007/s00705-020-04809-x. Epub 2020 Sep 16.
Porcine circovirus-like virus P1 is a novel circovirus that was originally detected in China in 2005. Here, we report the genome sequences of P1 isolates JS02, JS03, and HuN06, each with 163 amino acids in its capsid protein. The complete genome of each of these isolates contains 649 nucleotides and has a T insertion at position 207. Phylogenetic analysis based on complete genome sequences of 18 P1 reference strains grouped 16 P1 sequences from this study into one cluster, with the JS02, JS03, and HuN06 isolates forming an independent clade. However, phylogenetic analysis based on amino acid sequences of the capsid protein showed that the JS02, JS03, and HuN06 strains were on the same large branch with PCV2, distinct from other P1 isolates. These results help us to understand the origin and evolution of P1.
猪圆环病毒样病毒 P1 是一种新型圆环病毒，于 2005 年在中国首次发现。在这里，我们报告了 P1 分离株 JS02、JS03 和 HuN06 的基因组序列，其衣壳蛋白均含有 163 个氨基酸。这三个分离株的完整基因组均包含 649 个核苷酸，在位置 207 处有 T 插入。基于 18 个 P1 参考株的完整基因组序列进行的系统进化分析将本研究中的 16 个 P1 序列分为一组，JS02、JS03 和 HuN06 分离株形成一个独立的分支。然而，基于衣壳蛋白氨基酸序列的系统进化分析表明，JS02、JS03 和 HuN06 株与 PCV2 位于同一大亚群上，与其他 P1 分离株不同。这些结果有助于我们了解 P1 的起源和进化。
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