Fuentes Cristina, Ruiz-Rico María, Fuentes Ana, Ruiz María José, Barat José Manuel
Department of Food Technology, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Department of Food Technology, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
J Hazard Mater. 2020 Nov 15;399:123120. doi: 10.1016/j.jhazmat.2020.123120. Epub 2020 Jun 11.
In this work, the biodurability of three silica particle types (synthetic amourphous silica, MCM-41 microparticles, MCM-41 nanoparticles) functionalised with three different essential oil components (carvacrol, eugenol, vanillin) was studied under conditions that represented the human gastrointestinal tract and lysosomal fluid. The effect of particle type, surface immobilised component and mass quantity on the physico-chemical properties of particles and silicon dissolution was determined. Exposure to biological fluids did not bring about changes in the zeta potential values or particle size distribution of the bare or functionalised materials, but the in vitro digestion process partially degraded the structure of the MCM-41 nanoparticles. Functionalisation preserved the structure of the MCM-41 nanoparticles after simulating an in vitro digestion process, and significantly decreased the amount of silicon dissolved after exposing different particles to both physiological conditions, independently of the essential oil component anchored to their surface. The MCM-41 microparticles showed the highest solubility, while synthetic amorphous silica presented the lowest levels of dissolved silicon. The study of these modified silica particles under physiological conditions could help to predict the toxicological behaviour of these new materials.
在本研究中，研究了三种用三种不同精油成分（香芹酚、丁香酚、香草醛）功能化的二氧化硅颗粒类型（合成无定形二氧化硅、MCM-41微粒、MCM-41纳米颗粒）在模拟人体胃肠道和溶酶体液的条件下的生物耐久性。确定了颗粒类型、表面固定成分和质量数量对颗粒物理化学性质和硅溶解的影响。暴露于生物流体中不会导致未修饰或功能化材料的zeta电位值或粒径分布发生变化，但体外消化过程会部分降解MCM-41纳米颗粒的结构。功能化在模拟体外消化过程后保留了MCM-41纳米颗粒的结构，并且在将不同颗粒暴露于两种生理条件后，显著降低了溶解的硅的量，这与锚定在其表面的精油成分无关。MCM-41微粒显示出最高的溶解度，而合成无定形二氧化硅的溶解硅水平最低。在生理条件下对这些改性二氧化硅颗粒的研究有助于预测这些新材料的毒理学行为。
