Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China.
Methods Mol Biol. 2021;2179:35-39. doi: 10.1007/978-1-0716-0779-4_6.
Epithelial Mesenchymal Transition (EMT) initially discovered as a key developmental mechanism is now shown to be indirectly involved in fibrosis and is contributing to the progression of carcinomas. Additionally, to transcription factors driving the morphological transition, novel mechanisms are now described to modulate the different features of the transition. The debate as to whether EMT is essential for the dissemination of carcinoma cells from the primary tumors is likely to be resolved soon, considering that EMT is not a linear transition from an epithelial to a mesenchymal state. Multiple intermediate states can be reached without involving the presence of some of known transcription factors initially described as indispensable for the acquisition of mesenchymal-like phenotypes.
上皮间质转化（EMT）最初被发现是一种关键的发育机制，现在被证明与纤维化间接相关，并促进了癌的进展。此外，除了转录因子驱动形态转变外，现在还描述了新的机制来调节转变的不同特征。关于 EMT 是否对癌细胞从原发性肿瘤扩散至关重要的争论可能很快就会得到解决，因为 EMT 不是从上皮状态到间充质状态的线性转变。在不涉及最初描述为获得间充质样表型所必需的一些已知转录因子的情况下，可以达到多个中间状态。
