• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用 RGD 肽修饰的钌（ii）光敏剂的双光子光动力肿瘤细胞消融。

Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(ii) photosensitiser.

机构信息

Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510275, China.

出版信息

Chem Commun (Camb). 2020 Oct 25;56(83):12542-12545. doi: 10.1039/d0cc04943c. Epub 2020 Sep 17.

DOI:10.1039/d0cc04943c
PMID:32940288
Abstract

An RGD-peptide conjugated ruthenium(ii) complex has been developed, which functions as a two-photon absorption (TPA) photodynamic therapy (PDT) agent for ablating tumours by selectively targeting the mitochondria of integrin αβ-rich tumour cells. This approach offers a new and effective design and application for tumour-targeting metallo-anticancer drugs via two-photon PDT.

摘要

一种 RGD-肽偶联的钌（II）配合物已被开发出来，它可作为双光子吸收（TPA）光动力治疗（PDT）剂，通过选择性靶向整合素αβ丰富的肿瘤细胞的线粒体来消融肿瘤。这种方法为通过双光子 PDT 实现肿瘤靶向金属抗癌药物提供了新的有效设计和应用。

相似文献

1
Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(ii) photosensitiser.利用 RGD 肽修饰的钌（ii）光敏剂的双光子光动力肿瘤细胞消融。
Chem Commun (Camb). 2020 Oct 25;56(83):12542-12545. doi: 10.1039/d0cc04943c. Epub 2020 Sep 17.
2
Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy.聚合物包裹钌多吡啶配合物用于肿瘤靶向的单光子和双光子光动力治疗。
ACS Appl Mater Interfaces. 2020 Dec 9;12(49):54433-54444. doi: 10.1021/acsami.0c16119. Epub 2020 Nov 25.
3
Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents.钌（II）多吡啶配合物作为线粒体靶向双光子光动力抗癌剂。
Biomaterials. 2015 Jul;56:140-53. doi: 10.1016/j.biomaterials.2015.04.002. Epub 2015 Apr 17.
4
Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy.高电荷钌（II）多吡啶配合物作为溶酶体定位的双光子光动力治疗光敏剂。
Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14049-52. doi: 10.1002/anie.201507800. Epub 2015 Oct 8.
5
Ruthenium(II) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells.钌（II）配合物作为用于针对三阴性乳腺癌细胞的肿瘤特异性光动力疗法的生物正交双光子光敏剂。
Chem Commun (Camb). 2021 May 4;57(36):4408-4411. doi: 10.1039/d1cc00661d.
6
A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy.一种用于肿瘤靶向双光子光动力治疗的生物素化钌（ii）光敏剂。
Chem Commun (Camb). 2019 Sep 10;55(73):10972-10975. doi: 10.1039/c9cc05826e.
7
Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy.Ru(II) 金属卟啉配合物作为单光子和双光子光动力治疗光敏剂的应用的关键综述。
Acc Chem Res. 2017 Nov 21;50(11):2727-2736. doi: 10.1021/acs.accounts.7b00180. Epub 2017 Oct 23.
8
Boosting two-photon photodynamic therapy with mitochondria-targeting ruthenium-glucose conjugates.用靶向线粒体的钌-葡萄糖缀合物增强双光子光动力疗法。
Chem Commun (Camb). 2020 May 28;56(43):5839-5842. doi: 10.1039/d0cc01148g. Epub 2020 Apr 24.
9
Strained ruthenium complexes are potent light-activated anticancer agents.负载钌的配合物是一种有效的光激活型抗癌试剂。
J Am Chem Soc. 2012 May 23;134(20):8324-7. doi: 10.1021/ja3009677. Epub 2012 May 11.
10
Amphiphilic Gemini Iridium(III) Complex as a Mitochondria-Targeted Theranostic Agent for Tumor Imaging and Photodynamic Therapy.两亲 Gemini 铱(III)配合物作为一种用于肿瘤成像和光动力治疗的线粒体靶向诊疗试剂。
ACS Appl Mater Interfaces. 2019 May 1;11(17):15276-15289. doi: 10.1021/acsami.9b01205. Epub 2019 Apr 19.

引用本文的文献

1
An iridium(iii) 3-chloro-6-thio-1,2,4,5-tetrazine complex for cysteine conjugation, bioimaging and photoactivated therapy.一种用于半胱氨酸偶联、生物成像和光活化治疗的铱(III) 3-氯-6-硫代-1,2,4,5-四嗪配合物。
RSC Chem Biol. 2025 May 7. doi: 10.1039/d4cb00316k.
2
Near-Infrared Bioimaging Using Two-photon Fluorescent Probes.使用双光子荧光探针的近红外生物成像
Adv Healthc Mater. 2025 Jan;14(3):e2403272. doi: 10.1002/adhm.202403272. Epub 2024 Nov 21.
3
Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics.
利用过渡金属配合物的光功能设计创新的光疗方法。
Small Methods. 2024 Nov;8(11):e2400563. doi: 10.1002/smtd.202400563. Epub 2024 Sep 25.
4
Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors.环状钌-肽缀合物作为整合素靶向光治疗前药治疗脑肿瘤。
J Am Chem Soc. 2023 Jul 12;145(27):14963-14980. doi: 10.1021/jacs.3c04855. Epub 2023 Jun 28.
5
Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy.用于靶向抗癌治疗的基于肽的生物共轭物和疗法。
Pharmaceutics. 2022 Jun 29;14(7):1378. doi: 10.3390/pharmaceutics14071378.
6
Recent advances in noble metal complex based photodynamic therapy.基于贵金属配合物的光动力疗法的最新进展
Chem Sci. 2022 Apr 1;13(18):5085-5106. doi: 10.1039/d1sc05478c. eCollection 2022 May 11.
7
Asymmetric, amphiphilic RGD conjugated phthalocyanine for targeted photodynamic therapy of triple negative breast cancer.不对称、两亲性 RGD 共轭酞菁用于三阴性乳腺癌的靶向光动力治疗。
Signal Transduct Target Ther. 2022 Feb 28;7(1):64. doi: 10.1038/s41392-022-00906-2.
8
Emerging Molecular Receptors for the Specific-Target Delivery of Ruthenium and Gold Complexes into Cancer Cells.新兴的分子受体可将钌和金配合物特异性靶向递送至癌细胞。
Molecules. 2021 May 25;26(11):3153. doi: 10.3390/molecules26113153.