Hariri Nastaran, Darafshi Ghahroudi Sahar, Jahangiri Siroos, Borumandnia Nasrin, Narmaki Elham, Saidpour Atoosa
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Social Security Organization, Tehran, Iran.
Phytother Res. 2020 Nov;34(11):3041-3051. doi: 10.1002/ptr.6737. Epub 2020 Jul 1.
Oxidative stress and inflammation play pivotal roles in the pathophysiology of obesity and depression. This study aimed to evaluate the effects of sumac (Rhus coriaria L.) on anthropometric indices, oxidative stress, inflammation, and depression in overweight or obese depressed women.
This randomized, double-blind, placebo-controlled clinical trial was conducted on overweight or obese women aged 20-65 years with mild to moderate depression. The participants (n = 62) were assigned to receive a restricted calorie diet (RCD) plus 3 g/day of either sumac or placebo for 12 weeks. Anthropometric measurements, biochemical biomarkers, and the Beck depression inventory were assessed during the study.
Sumac significantly reduced weight, body mass index, body fat (p < .001), visceral fat level (p = .03), waist and hip circumference, and malondialdehyde levels (p = .03, p = .002, and p = .006, respectively) in comparison with the placebo group. The levels of interleukin-6 and tumor necrosis factor-α decreased only in the sumac group (11 and 32%, respectively); however, these reductions were not significant. The high-sensitivity c-reactive protein levels (p = .007 and p = .01, respectively) and Beck scores (p < .001) decreased significantly in both the sumac and the placebo group without any significant difference between the two groups.
Sumac can be considered as a functional food that along with RCD could have beneficial effects on obesity management, through the possible modulatory effects on oxidative stress in overweight or obese depressed women.
氧化应激和炎症在肥胖和抑郁症的病理生理学中起关键作用。本研究旨在评估漆树（Rhus coriaria L.）对超重或肥胖的抑郁女性的人体测量指标、氧化应激、炎症和抑郁的影响。
本随机、双盲、安慰剂对照临床试验针对年龄在20 - 65岁、患有轻度至中度抑郁症的超重或肥胖女性进行。参与者（n = 62）被分配接受限制热量饮食（RCD），并每天服用3克漆树或安慰剂，为期12周。在研究期间评估人体测量指标、生化生物标志物和贝克抑郁量表。
与安慰剂组相比，漆树显著降低了体重、体重指数、体脂（p <.001）、内脏脂肪水平（p =.03）、腰围和臀围以及丙二醛水平（分别为p =.03、p =.002和p =.006）。白细胞介素 - 6和肿瘤坏死因子 - α水平仅在漆树组下降（分别为11%和32%）；然而，这些下降并不显著。高敏C反应蛋白水平（分别为p =.007和p =.01）和贝克评分（p <.001）在漆树组和安慰剂组均显著下降，两组之间无显著差异。
漆树可被视为一种功能性食品，与RCD一起，通过对超重或肥胖的抑郁女性的氧化应激可能具有调节作用，从而对肥胖管理产生有益影响。
