Department of Health, Kinesiology, and Applied Physiology, Concordia University, and Montréal Behavioural Medicine Centre, CIUSSS-NIM, Hôpital du Sacré-Coeur de Montréal, Montréal, Quebec, Canada.
Faculty of Nutrition Sciences and Food Technology, Department of Clinical Nutrition & Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytother Res. 2021 Feb;35(2):987-995. doi: 10.1002/ptr.6859. Epub 2020 Oct 12.
Grape seed extract (GSE) is a flavonoid-rich supplement, recently discussed as a potential moderator of inflammation and obesity. In this study, we aimed to investigate the effects of GSE supplementation along with a restricted-calorie diet (RCD), on changes in blood lipid profile, visceral adiposity index (VAI), and atherogenic index of plasma (AIP). We designed a randomized, double-blinded, placebo-controlled clinical trial. Forty obese or overweight individuals (25 ≤ body mass index < 40 kg/m ) were randomly assigned to receive GSE (300 mg/day) or placebo, plus RCD, for 12 weeks. We studied the anthropometric measures, biochemical biomarkers and dietary intake within the study timelines. Levels of high-density lipoprotein cholesterol (HDL-C) and HDL-C/low-density lipoprotein cholesterol (LDL-C) significantly increased in the GSE group as compared with the placebo group at week 12 (p = .03 and .008, respectively, adjusted for age, sex, energy and saturated fatty acid intake). We also observed a significant reduction in LDL-C following GSE supplementation in comparison to placebo (adjusted for age, sex and energy intake, p = .04). VAI, AIP, total cholesterol and triglyceride significantly decreased in the GSE group compared with the baseline (p = .04, .02, .01, and .02, respectively). GSE supplementation may have a modulatory role in improving blood lipid profile in obese or overweight individuals, when accompanied by RCD.
葡萄籽提取物（GSE）是一种富含类黄酮的补充剂，最近被讨论为一种潜在的炎症和肥胖调节剂。在这项研究中，我们旨在研究 GSE 补充剂与限制热量饮食（RCD）一起对血脂谱、内脏脂肪指数（VAI）和血浆致动脉粥样硬化指数（AIP）变化的影响。我们设计了一项随机、双盲、安慰剂对照的临床试验。40 名肥胖或超重者（25≤体重指数<40kg/m ）被随机分为 GSE（300mg/天）或安慰剂组，同时接受 RCD 治疗 12 周。我们在研究期间研究了人体测量指标、生化生物标志物和饮食摄入。与安慰剂组相比，GSE 组在第 12 周时高密度脂蛋白胆固醇（HDL-C）和 HDL-C/低密度脂蛋白胆固醇（LDL-C）水平显著升高（分别调整年龄、性别、能量和饱和脂肪酸摄入后，p=0.03 和 0.008）。与安慰剂相比，我们还观察到 GSE 补充后 LDL-C 显著降低（调整年龄、性别和能量摄入后，p=0.04）。与基线相比，GSE 组的 VAI、AIP、总胆固醇和甘油三酯均显著降低（分别调整年龄、性别和能量摄入后，p=0.04、0.02、0.01 和 0.02）。GSE 补充剂可能在肥胖或超重者中与 RCD 一起具有改善血脂谱的调节作用。
