Department of Pediatrics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People's Republic of China.
Xiaorong Luo's Renowned Expert Inheritance Studio, 3Rd Floor, East District, Guangdong Provincial Hospital of Chinese Medicine, No.111, Dade Road, Yuexiu District, Guangzhou, Guangdong Province, 510120, People's Republic of China.
Biol Trace Elem Res. 2024 Oct;202(10):4440-4449. doi: 10.1007/s12011-023-04037-9. Epub 2023 Dec 29.
This study was to assess the individual effects of serum copper levels and environmental tobacco exposure and their joint effects on the risk of overweight and obesity among children and adolescents of 6 to 19 year olds. We analyzed cross-sectional data from 1849 children and adolescents participating in the National Health and Nutrition Examination Survey (NHANES) collected between 2011 and 2016. Environmental tobacco exposure was determined by cotinine levels. The serum copper level was divided into < median group and ≥ median groups according to the median of 109.81 µg/dL. The outcome was overweight/obese in children and adolescents. Weighted multinomial multivariate logistic regression models were used to assess the association of serum copper and cotinine levels, with the risk of overweight/obesity, and the joint effects on the risk of overweight and obesity among children and adolescents. The subgroup analyses based on age, gender, and household smoking status were conducted. Among 1849 children and adolescents, 332 children and adolescents had overweight BMI, and 450 children and adolescents had obese BMI. Higher serum copper levels were associated with the risk of obesity in children and adolescents (odds ratio (OR) 2.96, 95% confidence interval (CI) 1.39-6.31, P = 0.006). A positive association between increasing levels of cotinine levels and the risk of overweight (OR 1.83, 95% CI 1.16-2.87, P = 0.010) and obesity (OR 2.56, 95% CI 1.03-6.40, P = 0.044) in children and adolescents was observed. A remarkable association was found between higher serum copper in combination with higher cotinine levels and the risk of overweight (OR 3.23, 95% CI 1.19-8.83, P = 0.023) and obesity (OR 8.76, 95% CI 2.14-35.87, P = 0.003) in children and adolescents. The subgroup analyses revealed positive associations between high serum copper levels in combination with high cotinine levels and overweight and obesity in children and adolescents aged ≥ 12 years, of female sex, and without smoking family members. There may exist a joint effect of serum copper levels and environmental tobacco exposure on overweight/obesity among children and adolescents. These findings offer an insight that early weight control and reduction of tobacco exposure and the detection of serum copper levels may be important in reducing the risk of obesity in children.
本研究旨在评估血清铜水平和环境烟草暴露的个体效应及其对 6 至 19 岁儿童和青少年超重和肥胖风险的联合效应。我们分析了 2011 年至 2016 年期间参加国家健康和营养检查调查（NHANES）的 1849 名儿童和青少年的横断面数据。环境烟草暴露通过可替宁水平来确定。根据 109.81µg/dL 的中位数，将血清铜水平分为<中位数组和≥中位数组。该研究的结局为儿童和青少年超重/肥胖。使用加权多变量多元逻辑回归模型来评估血清铜和可替宁水平与超重/肥胖风险之间的关联，以及它们对儿童和青少年超重和肥胖风险的联合效应。根据年龄、性别和家庭吸烟状况进行了亚组分析。在 1849 名儿童和青少年中，有 332 名儿童和青少年超重 BMI，有 450 名儿童和青少年肥胖 BMI。较高的血清铜水平与儿童和青少年肥胖的风险相关（比值比[OR]2.96，95%置信区间[CI]1.39-6.31，P=0.006）。随着可替宁水平的升高，儿童和青少年超重的风险呈正相关（OR 1.83，95%CI 1.16-2.87，P=0.010）和肥胖（OR 2.56，95%CI 1.03-6.40，P=0.044）。在儿童和青少年中，较高的血清铜与较高的可替宁水平相结合与超重（OR 3.23，95%CI 1.19-8.83，P=0.023）和肥胖（OR 8.76，95%CI 2.14-35.87，P=0.003）的风险显著相关。亚组分析显示，在年龄≥12 岁、女性和无吸烟家庭成员的儿童和青少年中，高血清铜水平与高可替宁水平相结合与超重和肥胖呈正相关。血清铜水平和环境烟草暴露之间可能存在联合作用，影响儿童和青少年的超重/肥胖。这些发现提示，早期控制体重、减少烟草暴露和检测血清铜水平可能有助于降低儿童肥胖的风险。
