Department of Chemistry, The University of Alberta, Edmonton, Alberta, Canada, T6G 2G2.
Institute of Biological Chemistry, Academia Sinica, Academia Road, Section 2, #128, Nangang, Taipei 11529, Taiwan.
Org Lett. 2020 Oct 2;22(19):7645-7649. doi: 10.1021/acs.orglett.0c02839. Epub 2020 Sep 17.
Chloroviruses produce a capsid protein containing -linked glycans differing in structure from those found in all other organisms. These species feature a core "hyper-branched" fucose residue in which every hydroxyl group is glycosylated. We describe the synthesis of a nonasaccharide from chlorella virus 1, one of most complex chlorovirus -glycans reported, using a "counterclockwise" strategy involving the sequential addition of trisaccharide, disaccharide, and monosaccharide motifs to a trisaccharide containing the core fucose residue.
噬藻体病毒产生一种衣壳蛋白，其中含有β-连接的聚糖，其结构与所有其他生物体中的聚糖不同。这些物种的核心特征是“超支化”岩藻糖残基，其中每个羟基都被糖基化。我们使用“逆时针”策略，通过顺序添加三糖、二糖和单糖基序到含有核心岩藻糖残基的三糖，合成了一种来自于 chlorella 病毒 1 的九糖，这是报道的最复杂的噬藻体病毒-聚糖之一。
